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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $228 | In Stock | |
5 mg | $679 | In Stock | |
10 mg | $987 | In Stock | |
25 mg | $1,670 | In Stock | |
50 mg | $2,180 | In Stock | |
100 mg | $2,800 | In Stock |
Description | Plogosertib (CYC140) is an orally active, selective, potent, and ATP-competitive PLK1 inhibitor with an IC50 value of 3 nM.Plogosertib exhibits antiproliferative and anticancer activity and can be used for the study of solid and hematologic tumors. and hematologic tumors. |
In vitro | In KYSE-410 cells, Plogosertib (0, 0.07, 0.15, 0.3, 0.6, 1.25 μM; 72 hours) inhibits cell proliferation in a concentration-dependent manner[2]. |
In vivo | In the HL60 promyelocytic leukemia xenograft model, Plogosertib (40, 54, 67 mg/kg, qd 5/2/5; oral administration) inhibited tumor growth (>87%) without significant loss in body weight[2]. |
Alias | CYC140 |
Molecular Weight | 616.797 |
Formula | C34H48N8O3 |
Cas No. | 1137212-79-3 |
Storage | keep away from direct sunlight,keep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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