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DHMEQ racemate
DHMEQ racemate is an NF-κB inhibitor. The activity of DHMEQ racemate is lower than (-)-DHMEQ.
Catalog No. T11018Cas No. 287194-38-1
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DHMEQ racemate
Catalog No. T11018Alias rel-DHMEQCas No. 287194-38-1
DHMEQ racemate is an NF-κB inhibitor. The activity of DHMEQ racemate is lower than (-)-DHMEQ.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $1,670 | 6-8 weeks | |
| 50 mg | $2,180 | 6-8 weeks | |
| 100 mg | $2,800 | 6-8 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | DHMEQ racemate is an NF-κB inhibitor. The activity of DHMEQ racemate is lower than (-)-DHMEQ. |
| In vitro | DHMEQ racemate (DHM3EQ) and (-)-DHMEQ (DHM2EQ) inhibit TNF-a-induced NF-kB activation, with (-)-DHMEQ being more effective and less toxic. |
| In vivo | The anti-arthritis effect of (-)-DHMEQ (DHM2EQ) and DHMEQ racemate (DHM3EQ) on type II collagen-induced arthritis in DBA1/J mice was studied. Because of its pathological similarity to human rheumatoid arthritis, this animal model is widely used to evaluate anti-rheumatic drugs. Cause arthritis and score it. (-)-DHMEQ significantly inhibited type II collagen-induced arthritis in mice, while DHMEQ racemates tended to only slightly inhibit it. |
| Alias | rel-DHMEQ |
| Molecular Weight | 261.23 |
| Formula | C13H11NO5 |
| Cas No. | 287194-38-1 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 32 mg/mL (122.50 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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