Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethynylcytidine is a nucleoside antimetabolite.
Description | Ethynylcytidine is a nucleoside antimetabolite. |
In vitro | The cytotoxicity of Ethynylcytidine tends to become stronger as the exposure time becomes longer. The IC50 values of Ethynylcytidine in the five human tumors with 4, 24 and 72 h exposure range from 0.114 to 1.032 μM, 0.015 to 0.067 μM, and 0.008 to 0.058 μM, respectively. The differences in IC50 values between the 24 and 72 h exposure times are not large, and Ethynylcytidine appears to show sufficiently potent cytotoxicity at the 24 h exposure time in all 5 human tumors. |
In vivo | In both OCUM-2MD3 and LX-1 xenograft models, Ethynylcytidine demonstrates notable tumor regression and a potent antitumor efficacy, achieving a tumor growth inhibition (IR) rate of about 90% or higher by day 15 at minimally toxic doses across all three dosing schedules. Specifically, a weekly administration of Ethynylcytidine at 6 mg/kg leads to a significant reduction in LX-1 tumor size, with an IR of 98%. Conversely, administering Ethynylcytidine three or five times weekly yields a strong antitumor response with an IR of approximately 85%, whereas a once-weekly treatment regimen results in a less than 60% IR, indicating a comparatively weaker antitumor activity. |
Synonyms | ECyD, 3'-C-Ethynylcytidine, TAS-106 |
Molecular Weight | 267.24 |
Formula | C11H13N3O5 |
CAS No. | 180300-43-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 240 mg/mL (898.07 mM), Sonification is recommended.
You can also refer to dose conversion for different animals. More
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Ethynylcytidine 180300-43-0 Cell Cycle/Checkpoint DNA Damage/DNA Repair Nucleoside Antimetabolite/Analog ECyD 3'-C-Ethynylcytidine TAS106 TAS 106 TAS-106 inhibitor inhibit