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FKBP12 PROTAC RC32

Catalog No. T13694 CAS 2375555-66-9

Synonyms: RC32

FKBP12 PROTAC RC32 contains conjugation of Rapamycin and a ligand for an E3 ubiquitin ligase.FKBP12 PROTAC RC32 (RC32) is a potent FKBP12 degrader based on PROTAC technology.

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FKBP12 PROTAC RC32, CAS 2375555-66-9

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Description	FKBP12 PROTAC RC32 contains conjugation of Rapamycin and a ligand for an E3 ubiquitin ligase.FKBP12 PROTAC RC32 (RC32) is a potent FKBP12 degrader based on PROTAC technology.
In vitro	FKBP12 PROTAC RC32 (RC32;?0.1-1000 nM;?for 12?hours) results in 50% protein degradation (DC50) of ~0.3?nM after only 12?hours of treatment.
In vivo	RC32 efficiently degrades the FKBP12 protein in most of the organs examined in Bama pigs (20?kg) . ?RC32 efficiently degrades FKBP12 in the heart, liver, kidney, spleen, lung, and stomach of rhesus monkeys.?RC32 degrades the FKBP12 protein in most of the organs of treated mice, except for the brain after only 1 day of treatment in mice. ?RC32 significantly degrades FKBP12 in mice.

Synonyms	RC32
Molecular Weight	1426.69
Formula	C75H107N7O20
CAS No.	2375555-66-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. A chemical approach for global protein knockdown from mice to non-human primates. Cell Discov. 2019 Feb 5;5:10.

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Keywords

FKBP12 PROTAC RC32 2375555-66-9 Others RC-32 RC 32 FKBP-12 PROTAC RC32 RC32 inhibitor inhibit

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