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GLN-1062 is a pro-drug of galantamine and liberates galantamine on cleavage by a carboxyesterase in the brain.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $34 | In Stock | |
5 mg | $77 | In Stock | |
10 mg | $119 | In Stock | |
25 mg | $238 | In Stock | |
50 mg | $371 | In Stock | |
100 mg | $521 | In Stock | |
200 mg | $718 | In Stock | |
1 mL x 10 mM (in DMSO) | $86 | In Stock |
Description | Memogain is a pro-drug of galantamine. It is used for the treatment of Alzheimer's disease. |
In vivo | GLN-1062 has more than 15-fold higher bioavailability in the brain than the same doses of galantamine. In animal models of drug-induced amnesia, GLN-1062 produced several fold larger cognitive improvement than the same doses of galantamine, without exhibiting any significant levels of gastrointestinal side effects that are typical for the unmodified drug and other inhibitors of cholinesterases, such as donepezil and rivastigmin. In the ferret, dramatically reduced emetic and behavioral responses were observed when GLN-1062 was administered instead of galantamine[1]. |
Molecular Weight | 391.46 |
Formula | C24H25NO4 |
Cas No. | 224169-27-1 |
Smiles | [H][C@]12C[C@@H](OC(=O)c3ccccc3)C=C[C@]11CCN(C)Cc3ccc(OC)c(O2)c13 |
Relative Density. | 1.28 g/cm3 (Predicted) |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 45 mg/mL (114.95 mM) ![]() | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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