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GSK 3008348 hydrochloride
GSK 3008348 hydrochloride is an αvβ6 integrin inhibitor used to confirm idiopathic pulmonary fibrosis.
Catalog No. T15583Cas No. 1629249-40-6
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GSK 3008348 hydrochloride
Catalog No. T15583Alias GSK-3008348 hydrochloride, GSK3008348 hydrochlorideCas No. 1629249-40-6
GSK 3008348 hydrochloride is an αvβ6 integrin inhibitor used to confirm idiopathic pulmonary fibrosis.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $89 | Backorder | |
| 5 mg | $247 | Backorder | |
| 10 mg | $347 | Backorder | |
| 25 mg | $579 | Backorder | |
| 50 mg | $828 | Backorder | |
| 100 mg | $1,160 | Backorder |
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Product Introduction
Bioactivity
Chemical Properties
| Description | GSK 3008348 hydrochloride is an αvβ6 integrin inhibitor used to confirm idiopathic pulmonary fibrosis. |
| Targets&IC50 | ανβ5:6.9 (pIC50), ανβ3:6 (pIC50), αvβ6:8.4 (pIC50), ανβ8:7.7 (pIC50) |
| In vitro | b>METHODS: GSK 3008348 hydrochloride was subjected to fluorescence polarization assay. RESULTS: The affinity of GSK 3008348 hydrochloride for human-6 protein was 8.1 (pIC50), while its affinity in the cell adhesion assay was: 6 (pIC50) for ανβ3; 6.9 (pIC50) for ανβ5; 8.4 (pIC50) for αvβ6; and 7.7 (pIC50) for ανβ8. [1] |
| Alias | GSK-3008348 hydrochloride, GSK3008348 hydrochloride |
| Formula | C29H37N5O2 xHCl |
| Cas No. | 1629249-40-6 |
Storage & Solubility Information
| Storage | store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO: 11.66 mg/mL, Sonication and heating are recommended. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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