Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Hibifolin is a flavonol glycoside natural product,is a potential inhibitor of adenosine deaminase (Ki of 49.92 μM). Hibifolin protects neurons against beta-amyloid-induced neurotoxicity.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 54.00 | |
5 mg | In stock | $ 122.00 | |
10 mg | In stock | $ 178.00 | |
25 mg | In stock | $ 297.00 | |
50 mg | In stock | $ 453.00 | |
100 mg | In stock | $ 655.00 |
Description | Hibifolin is a flavonol glycoside natural product,is a potential inhibitor of adenosine deaminase (Ki of 49.92 μM). Hibifolin protects neurons against beta-amyloid-induced neurotoxicity. |
Targets&IC50 | ADA:49.92 μM (Ki) |
In vitro | the inhibitory activity of a plant flavonoid, hibifolin on ADA is investigated using enzyme kinetic assay and isothermal titration calorimetry.?The inhibitory constant of hibifolin was found to be 49.92μM 3.98 and the mode of binding was reversible.?Isothermal titration calorimetry showed that the compound binds ADA with binding energy of -7.21Kcal/mol.?The in silico modeling and docking studies showed that the bound ligand is stabilized by hydrogen bonds with active site residues of the enzyme.?hibifolin can act as a potential inhibitor of ADA. |
Source |
Molecular Weight | 494.36 |
Formula | C21H18O14 |
CAS No. | 55366-56-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 5 mM
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Hibifolin 55366-56-8 Metabolism Adenosine deaminase Adenosine Deaminase adenosine anti-proliferative anti-inflammatory neurotoxicity Inhibitor deaminase inhibit inhibitor