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JDTic dihydrochloride

JDTic dihydrochloride
JDTic is a powerful antagonist of kappa-opioid receptors (KOR), effectively inhibiting the antinociceptive effects induced by the κ-agonist U50, 488.
Catalog No. T11721LCas No. 785835-79-2
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JDTic dihydrochloride

Catalog No. T11721LCas No. 785835-79-2
JDTic is a powerful antagonist of kappa-opioid receptors (KOR), effectively inhibiting the antinociceptive effects induced by the κ-agonist U50, 488.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
2 mg$1065 days
25 mg$66810-14 weeks
50 mg$86810-14 weeks
100 mg$1,29010-14 weeks
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Product Introduction

Bioactivity
Description
JDTic is a powerful antagonist of kappa-opioid receptors (KOR), effectively inhibiting the antinociceptive effects induced by the κ-agonist U50, 488.
In vivo
JDTic administered intraperitoneally (i.p.) at a dose of 10 mg/kg effectively reduces alcohol self-administration, inhibits cue-induced alcohol seeking, and selectively antagonizes the effects of a kappa-opioid receptor (KOR) agonist 2 hours after treatment. At a higher dose (30 mg/kg) given intragastrically (i.g.), JDTic significantly prevents U50,488-induced diuresis in rats. When administered subcutaneously (s.c.) in doses ranging from 2.5 to 16 mg/kg, JDTic dose-dependently inhibits the antinociceptive effects of nicotine in the tail-flick test without affecting outcomes in the hot-plate test or altering body temperature in nicotine-injected mice. Additionally, a 3 mg/kg i.p. dose of JDTic effectively ameliorates anxiety-like behavior in a rat model of hangover anxiety.
Chemical Properties
Molecular Weight538.55
FormulaC28H41Cl2N3O3
Cas No.785835-79-2
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
H2O: 50 mg/mL (92.84 mM), Sonication is recommended.
DMSO: 100 mg/mL (185.68 mM), Sonication is recommended.
Solution Preparation Table
H2O/DMSO
1mg5mg10mg50mg
1 mM1.8568 mL9.2842 mL18.5684 mL92.8419 mL
5 mM0.3714 mL1.8568 mL3.7137 mL18.5684 mL
10 mM0.1857 mL0.9284 mL1.8568 mL9.2842 mL
20 mM0.0928 mL0.4642 mL0.9284 mL4.6421 mL
50 mM0.0371 mL0.1857 mL0.3714 mL1.8568 mL
DMSO
1mg5mg10mg50mg
100 mM0.0186 mL0.0928 mL0.1857 mL0.9284 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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2 Enter the in vivo formulation:
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