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L162389
L162389 is an orally active and potent angiotensin II receptor antagonist with a balanced affinity for AT1 and AT2 receptor subtypes that stimulates the conversion of phosphatidylinositol.
Catalog No. T11808Cas No. 169281-53-2
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Purity:99.68%
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L162389
Catalog No. T11808Alias L 162389, L-162389Cas No. 169281-53-2
L162389 is an orally active and potent angiotensin II receptor antagonist with a balanced affinity for AT1 and AT2 receptor subtypes that stimulates the conversion of phosphatidylinositol.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $333 | In Stock | |
| 5 mg | $790 | In Stock | |
| 10 mg | $1,120 | In Stock | |
| 25 mg | $1,670 | In Stock | |
| 50 mg | $2,180 | In Stock |
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CitedProduct Introduction
Bioactivity
Chemical Properties
| Description | L162389 is an orally active and potent angiotensin II receptor antagonist with a balanced affinity for AT1 and AT2 receptor subtypes that stimulates the conversion of phosphatidylinositol. |
| Targets&IC50 | AT1 receptor:28 nM (Ki) |
| In vitro | METHODS: To determine the characteristics of the non-peptide angiotensin AT1 ligand L162389, a series of affinity assay studies were conducted. RESULTS: L162389 also stimulated phosphatidylinositol turnover, although only a minor fraction of the angiotensin response, acting as an angiotensin antagonist with an IC50 of 105 nM [1]. |
| Alias | L 162389, L-162389 |
| Molecular Weight | 562.72 |
| Formula | C31H38N4O4S |
| Cas No. | 169281-53-2 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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