store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
LCB-2853 is a potent thromboxane A2/prostaglandin H2 (TXA2/PGH2) receptor antagonist with antiplatelet aggregation, antivasospasm, and antithrombotic effects.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 700.00 | |
5 mg | In stock | $ 1,800.00 |
Description | LCB-2853 is a potent thromboxane A2/prostaglandin H2 (TXA2/PGH2) receptor antagonist with antiplatelet aggregation, antivasospasm, and antithrombotic effects. |
In vivo | In dog coronary stenosis, LCB 2853 demonstrates very high efficacy with an ED50 of 7.2 μg/kg. In rat venous thrombosis induced by a combination of venous injury and blood stasis, perfused LCB 2853 reduces the weight of thrombi in a dose-related manner with an ED50 of 220 μg/kg/min[1]. In vivo, LCB 2853 exhibits an ED50 lower than 1 mg/kg i.v. against both platelet aggregation and vasoconstriction. This is observed in rat arachidonic acid (AA)-induced thrombocytopenia or U 46619-induced hypertension (ED50 = 0.25 and 0.16 mg/kg) as well as in AA-induced sudden death in mice (ED50 = 0.44 mg/kg). Furthermore, LCB 2853 effectively blocks U 46619-induced bronchoconstriction after i.v. administration (ED50 = 18.4 μg/kg)[2]. |
Molecular Weight | 421.94 |
Formula | C21H24ClNO4S |
CAS No. | 141335-10-6 |
store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
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LCB-2853 141335-10-6 DNA Damage/DNA Repair Metabolism PPAR LCB2853 LCB 2853 inhibitor inhibit