Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Lumicitabine (ALS-008176) is an inhibitor of RSV polymerase.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | 5 days | $ 347.00 | |
10 mg | 5 days | $ 541.00 | |
1 mL * 10 mM (in DMSO) | 5 days | $ 329.00 |
Description | Lumicitabine (ALS-008176) is an inhibitor of RSV polymerase. |
In vivo | In an adult human challenge study, Lumicitabine has shown efficacy against RSV infection[1]. Lumicitabine solubility is adequate to support oral administration in solutions with a relatively low percentage of organic solvent and in aqueous suspensions. High levels of NMP and NTP are obtained following the oral administration of Lumicitabine to monkeys [2]. |
Animal Research | Rats: Lumicitabine is formulated as solutions in PEG400-based vehicles. Pharmacokinetic studies are conducted at 5 mg/kg and for oral PK studies, the prodrugs are administered at 5 mg/kg parent nucleoside equivalent doses. Blood samples are typically collected at various time points up to 24 h post dose for rat [2]. Monkeys: Lumicitabine is formulated as a solution in PEG400-based vehicles. Pharmacokinetic studies are conducted at 5 mg/kg and for oral PK studies, the prodrugs are administered at 5 mg/kg parent nucleoside equivalent doses. Blood samples are typically collected at various time points up to 12 h post dose for Monkeys [2]. |
Synonyms | ALS-8176, ALS-008176 |
Molecular Weight | 433.86 |
Formula | C18H25ClFN3O6 |
CAS No. | 1445385-02-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 48 mg/mL (110.63 mM)
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Lumicitabine 1445385-02-3 Microbiology/Virology RSV ALS-8176 ALS8176 ALS 8176 ALS008176 ALS 008176 ALS-008176 inhibitor inhibit