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VV116
🥰Excellent
Catalog No. T60016Cas No. 2647442-33-7
Alias JT001, GS-621763-d1
VV116 is a selective and orally active nucleoside antiviral agent against respiratory syncytial virus and SARS-CoV-2 infection.[1]
VV116
🥰Excellent
Purity: 99.42%
Catalog No. T60016Alias JT001, GS-621763-d1Cas No. 2647442-33-7
VV116 is a selective and orally active nucleoside antiviral agent against respiratory syncytial virus and SARS-CoV-2 infection.[1]
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $93 | In Stock | |
| 5 mg | $228 | In Stock | |
| 10 mg | $363 | In Stock | |
| 25 mg | $690 | In Stock | |
| 50 mg | $977 | In Stock | |
| 100 mg | $1,290 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $295 | In Stock |
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Purity:99.42%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | VV116 is a selective and orally active nucleoside antiviral agent against respiratory syncytial virus and SARS-CoV-2 infection.[1] |
| In vitro | VV116 (JT001) (0-1000 μM) inhibits RSV replication in A549 cells with an EC50 of 1.20 μM, a CC50 of 95.92 μM, and a selectivity index (SI) of 80[2]. |
| In vivo | METHODS: Mice were infected with MHV and orally treated with different concentrations (25 mg/kg, 50 mg/kg, and 100 mg/kg) of VV116 (JT001), and disease symptoms, including changes in body weight and mortality, were monitored daily.
RESULTS High-dose VV116 treatment effectively suppressed viral titers in vivo and alleviated weight loss caused by viral infection. [1] |
| Alias | JT001, GS-621763-d1 |
| Molecular Weight | 502.54 |
| Formula | C24H30DN5O7 |
| Cas No. | 2647442-33-7 |
| Smiles | C(#N)[C@@]1([C@H](OC(C(C)C)=O)[C@H](OC(C(C)C)=O)[C@@H](COC(C(C)C)=O)O1)C=2N3C(=C(C2)[2H])C(N)=NC=N3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 245 mg/mL (419.92 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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