Powder: -20°C for 3 years | In solvent: -80°C for 1 year
VV116 (JT001) is a selective and orally active nucleoside antiviral agent against respiratory syncytial virus (RSV) and SARS-CoV-2 infection.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 93.00 | |
5 mg | In stock | $ 228.00 | |
10 mg | In stock | $ 363.00 | |
25 mg | In stock | $ 690.00 | |
50 mg | In stock | $ 977.00 | |
100 mg | In stock | $ 1,290.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 295.00 |
Description | VV116 (JT001) is a selective and orally active nucleoside antiviral agent against respiratory syncytial virus (RSV) and SARS-CoV-2 infection. |
In vitro | VV116 (0-1000 μM) inhibited RSV replication in A549 cells with EC50 of 1.20 μM, CC50 of 95.92 μM and selectivity index (SI) of 80[2]. |
In vivo | In Balb/c mice, VV116 (25, 50 and 100 mg/kg; p.o.) exhibits favorable PK properties and good safety profile. VV116 (25, 50 and 100 mg/kg; p.o.) exhibits a stronger activity and decreases the virus titers below the detection limit at 50 mg/kg, also reduces lung injury after RSV infection[2]. |
Synonyms | GS-621763-d1, JT001 |
Molecular Weight | 502.54 |
Formula | C24H30DN5O7 |
CAS No. | 2647442-33-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 245 mg/mL (419.92 mM), Sonification is recommended.
You can also refer to dose conversion for different animals. More
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VV116 2647442-33-7 Microbiology/Virology SARS-CoV RSV VV-116 VV 116 GS-621763-d1 JT-001 JT 001 JT001 inhibitor inhibit