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Ziresovir

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Purity:100%

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COA HNMR HPLC

Ziresovir

Catalog No. T13401Cas No. 1422500-60-4

Ziresovir (RO-0529) is a respiratory syncytial virus fusion protein (RSV F) inhibitor that inhibits RSV activity and can be used in the study of syncytial virus sensing.

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Pack Size	Price	Availability
2 mg	$173	In Stock
5 mg	$289	In Stock
10 mg	$455	In Stock
25 mg	$818	In Stock
50 mg	$1,190	In Stock
100 mg	$1,630	In Stock
1 mL x 10 mM (in DMSO)	$279	In Stock

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Product Introduction

Bioactivity

Description	Ziresovir (RO-0529) is a respiratory syncytial virus fusion protein (RSV F) inhibitor that inhibits RSV activity and can be used in the study of syncytial virus sensing.
Targets&IC50	RSV F:3 nM (EC50)
In vitro	With EC50/EC90 values (μM) of 0.003/0.005 (WT), 2.1/10.0 (D486N), and >10/>10 (D489A), Ziresovir exhibits different efficacy in Wild Type (WT) and Mutant Strains RSV, respectively[1].Inhibiting the RSV F protein-induced cell–cell fusion process, RO-0529 (100 nM; 4 d) suppresses the syncytia formation induced by the RSV F protein[1].
In vivo	Ziresovir (12.5 mg/kg, 50 mg/kg; p.o.; twice daily; 4 d) reduces RSV titer in the mouse lung[1]. With a single oral dose of 10 mg/kg, Ziresovir exhibits good exposure and 32% bioavailability in male Wistar-Han rats[1]. A single oral dose of 150 mg/kg results in higher lung distribution than plasma in CD-1 mice[1].
Alias	AK0529, RO-0529

Chemical Properties

Molecular Weight	439.53
Formula	C22H25N5O3S
Cas No.	1422500-60-4

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 100 mg/mL (227.52 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2752 mL	11.3758 mL	22.7516 mL	113.7579 mL
5 mM	0.4550 mL	2.2752 mL	4.5503 mL	22.7516 mL
10 mM	0.2275 mL	1.1376 mL	2.2752 mL	11.3758 mL
20 mM	0.1138 mL	0.5688 mL	1.1376 mL	5.6879 mL
50 mM	0.0455 mL	0.2275 mL	0.4550 mL	2.2752 mL
100 mM	0.0228 mL	0.1138 mL	0.2275 mL	1.1376 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc