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MS 15203
🥰Excellent
Catalog No. T37131Cas No. 73912-52-4
Alias MS-0015203, MS0015203
MS 15203 is a selective GPR171 agonist that increases morphine antinociception and is effective in reducing chronic pain. It can reduce chronic neuropathic and inflammatory pain in male mice.
MS 15203
🥰Excellent
Catalog No. T37131Alias MS-0015203, MS0015203Cas No. 73912-52-4
MS 15203 is a selective GPR171 agonist that increases morphine antinociception and is effective in reducing chronic pain. It can reduce chronic neuropathic and inflammatory pain in male mice.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $38 | In Stock | |
| 5 mg | $60 | In Stock | |
| 10 mg | $106 | In Stock | |
| 25 mg | $222 | In Stock | |
| 50 mg | $328 | In Stock | |
| 100 mg | $492 | In Stock | |
| 500 mg | $1,070 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $68 | In Stock |
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | MS 15203 is a selective GPR171 agonist that increases morphine antinociception and is effective in reducing chronic pain. It can reduce chronic neuropathic and inflammatory pain in male mice. |
| Targets&IC50 | b-LEN:80 ± 1 nM |
| In vitro | To assess the selectivity of MS 15203 for GPR171, screened the ligand against a panel of 80 different transmembrane and soluble receptors, including ~70 GPCRs. MS 15203 dose-dependently displaced radiolabeled b-LEN from hypothalamic membranes with an affinity that was lower than that of b-LEN. IC50 = 80 ± 1 (nM). [1] |
| In vivo | To examine the effects of long-term activation of GPR171, administered MS 15203 (2.5 mg/kg) to mice by intraperitoneal injection every third day and fed a high-fat diet to exacerbate the effects of the compound. Knockdown of GPR171 in the hypothalamus significantly at tenuated MS 15203-induced weight gain, implying that chronic administration of MS 15203 affects body weight through GPR171. [1] |
| Alias | MS-0015203, MS0015203 |
| Molecular Weight | 249.22 |
| Formula | C12H11NO5 |
| Cas No. | 73912-52-4 |
| Smiles | O=C(O)C1=CC(=CC(=C1)C(=O)O)NC(=O)C(=C)C |
Storage & Solubility Information
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 40 mg/mL (160.50 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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