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Pack Size | Price | Availability | Quantity |
---|---|---|---|
10 μg (277.4 µM * 100 μL in Ethanol) | $193 | 35 days | |
25 μg (277.4 µM * 100 μL in Ethanol) | $450 | 35 days | |
50 μg (277.4 µM * 100 μL in Ethanol) | $850 | 35 days | |
100 μg (277.4 µM * 100 μL in Ethanol) | $1,500 | 35 days |
Description | Maresin 1 is a small molecule compound biosynthesized by macrophages (MΦ) with significant anti-inflammatory activity that attenuates LPS-induced lung injury in mice by inhibiting neutrophil adhesion and decreasing the levels of pro-inflammatory cytokines, and stimulates intracellular Ca2+ production and secretion. |
In vitro | In addition to reducing the production of IL-1β, TNF-α, IL-6, and INF-γ, Maresin 1 (MaR1, 300 nM) also diminishes neutrophil migration and the generation of reactive oxygen species [2]. |
In vivo | In a dose-dependent manner, Maresin 1 (MaR1) inhibits TRPV1 currents in neurons, blocking capsaicin-induced inward currents (IC50=0.49 nM), and alleviates inflammation and chemotherapy-induced neuropathic pain in mice [3].Maresin 1 (MaR1, 0.1, 0.3, and 1 μg/animal, iv) protects mice from acute DSS-induced colitis. Treatment with Maresin 1 (0.3 and 1 μg/animal, iv) significantly reduces macroscopic damage in the acute phase of DSS-induced colitis [2]. |
Molecular Weight | 360.49 |
Formula | C22H32O4 |
Cas No. | 1268720-28-0 |
Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||||||||||||
Solubility Information | DMF: 50 mg/mL PBS (pH 7.2): 0.05 mg/mL Ethanol: 40 mg/mL (110.95 mM), Sonication is recommended. DMSO: 40 mg/mL (110.95 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
Ethanol/DMSO
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