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NMDI14

Catalog No. T12235   CAS 307519-88-6

NMDI14 is an inhibitor of nonsense mediated RNA decay (NMD).

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NMDI14 Chemical Structure
NMDI14, CAS 307519-88-6
Pack Size Availability Price/USD Quantity
1 mg In stock $ 32.00
2 mg In stock $ 44.00
5 mg In stock $ 72.00
10 mg In stock $ 128.00
25 mg In stock $ 278.00
50 mg In stock $ 488.00
100 mg In stock $ 716.00
1 mL * 10 mM (in DMSO) In stock $ 79.00
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Purity: 99.37%
Purity: 99.37%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description NMDI14 is an inhibitor of nonsense mediated RNA decay (NMD).
In vitro NMDI14 Treating cells with NMDI14 for 6 hours leads to an increase of PTC 39 β globin to 12%, a relative four-fold increase that, if resulting in biologically active hemoglobin, would be sufficient to ameliorate the clinical symptoms of thalassemia[1].NMDI14, an inhibitor of nonsense-mediated mRNA decay (NMD), restored W1282X mRNA to almost 50% of WT levels in the parental NE cells. RNA-seq of the NE cells homozygous for W1282X showed that CFTR transcript level was reduced to 1.7% of WT (p-value: 4.6e-3). Negligible truncated CFTR protein was generated by Flp-In 293 cells stably expressing the W1282X EMG even though CFTR transcript was well above levels observed in the parents and proband. Finally,NMD inhibition improved the stability and response to correctors of W1282X-CFTR protein expressed in the Flp-In-293 cells[2].
Molecular Weight 415.51
Formula C21H25N3O4S
CAS No. 307519-88-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: <1mg/ml

TargetMolReferences and Literature

1. Martin L, et al. Identification and characterization of small molecules that inhibit nonsense-mediated RNA decay and suppress nonsense p53 mutations. Cancer Res. 2014 Jun 1;74(11):3104-1 2. Aksit M A , Bowling A D , Evans T A , et al. Decreased mRNA and protein stability of W1282X limits response to modulator therapy[J]. Journal of Cystic Fibrosis, 2019, 18(5).

Related compound libraries

This product is contained In the following compound libraries:
Inhibitor Library NO PAINS Compound Library Bioactive Compounds Library Max Bioactive Compound Library

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Keywords

NMDI14 307519-88-6 Others inhibit Inhibitor NMDI 14 NMDI-14 inhibitor

 

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