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(E/Z)-Rigosertib sodium

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Purity:99.82%

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COA HNMR HPLC

(E/Z)-Rigosertib sodium

Catalog No. T6070Cas No. 1225497-78-8

ON-01910 is a non-ATP-competitive PLK1 inhibitor(IC50 of 9 nM, in a cell-free assay). It shows 30-fold greater selectivity against Plk2 and no activity to Plk3. Rigosertib inhibits PI3K/Akt pathway and activates oxidative stress signals. Rigosertib induces apoptosis in various cancer cells.It is a synthetic benzyl styryl sulfone analogue with potential antineoplastic activity.

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Pack Size	Price	Availability
2 mg	$34	In Stock
5 mg	$55	In Stock
10 mg	$97	In Stock
25 mg	$193	In Stock
50 mg	$363	In Stock
100 mg	$622	In Stock
1 mL x 10 mM (in DMSO)	$72	In Stock

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Product Introduction

Bioactivity

Description	ON-01910 is a non-ATP-competitive PLK1 inhibitor(IC50 of 9 nM, in a cell-free assay). It shows 30-fold greater selectivity against Plk2 and no activity to Plk3. Rigosertib inhibits PI3K/Akt pathway and activates oxidative stress signals. Rigosertib induces apoptosis in various cancer cells.It is a synthetic benzyl styryl sulfone analogue with potential antineoplastic activity.
In vitro	ON01910, a small molecule inhibitor of Plk1 activity, which induces mitotic arrest of tumor cells characterized by spindle abnormalities leading to their apoptosis.?This compound was not ATP-competitive, but competed for the substrate binding site of the enzyme[1].
In vivo	In vivo, this compound did not exhibit hematotoxicity, liver damage, or neurotoxicity, and was a potent inhibitor of tumor growth in a variety of xenograft nude mouse models.?ON01910 showed strong synergy with several chemotherapeutic agents, often inducing complete regression of tumors[1].
Alias	(E/Z) ON-01910 sodium

Chemical Properties

Molecular Weight	473.47
Formula	C21H24NNaO8S
Cas No.	1225497-78-8

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 94 mg/mL (198.53 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1121 mL	10.5603 mL	21.1207 mL	105.6033 mL
5 mM	0.4224 mL	2.1121 mL	4.2241 mL	21.1207 mL
10 mM	0.2112 mL	1.0560 mL	2.1121 mL	10.5603 mL
20 mM	0.1056 mL	0.5280 mL	1.0560 mL	5.2802 mL
50 mM	0.0422 mL	0.2112 mL	0.4224 mL	2.1121 mL
100 mM	0.0211 mL	0.1056 mL	0.2112 mL	1.0560 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc