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(E/Z)-Rigosertib sodium

(E/Z)-Rigosertib sodium
ON-01910 is a non-ATP-competitive PLK1 inhibitor(IC50 of 9 nM, in a cell-free assay). It shows 30-fold greater selectivity against Plk2 and no activity to Plk3. Rigosertib inhibits PI3K/Akt pathway and activates oxidative stress signals. Rigosertib induces apoptosis in various cancer cells.It is a synthetic benzyl styryl sulfone analogue with potential antineoplastic activity.
Catalog No. T6070Cas No. 1225497-78-8
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Purity:99.82%
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(E/Z)-Rigosertib sodium

Catalog No. T6070Cas No. 1225497-78-8
ON-01910 is a non-ATP-competitive PLK1 inhibitor(IC50 of 9 nM, in a cell-free assay). It shows 30-fold greater selectivity against Plk2 and no activity to Plk3. Rigosertib inhibits PI3K/Akt pathway and activates oxidative stress signals. Rigosertib induces apoptosis in various cancer cells.It is a synthetic benzyl styryl sulfone analogue with potential antineoplastic activity.
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Pack SizePriceAvailabilityQuantity
2 mg$34In Stock
5 mg$55In Stock
10 mg$97In Stock
25 mg$193In Stock
50 mg$363In Stock
100 mg$622In Stock
1 mL x 10 mM (in DMSO)$72In Stock
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Product Introduction

Bioactivity
Description
ON-01910 is a non-ATP-competitive PLK1 inhibitor(IC50 of 9 nM, in a cell-free assay). It shows 30-fold greater selectivity against Plk2 and no activity to Plk3. Rigosertib inhibits PI3K/Akt pathway and activates oxidative stress signals. Rigosertib induces apoptosis in various cancer cells.It is a synthetic benzyl styryl sulfone analogue with potential antineoplastic activity.
Targets&IC50
PDGFR:18 nM(Cell-free assay) , FLK1:42 nM(Cell-free assay) , Src:55 nM(Cell-free assay) , PLK1:9 nM(Cell-free assay) , BCR-ABL:32 nM(Cell-free assay)
In vitro
ON01910, a small molecule inhibitor of Plk1 activity, which induces mitotic arrest of tumor cells characterized by spindle abnormalities leading to their apoptosis.?This compound was not ATP-competitive, but competed for the substrate binding site of the enzyme[1].
In vivo
In vivo, this compound did not exhibit hematotoxicity, liver damage, or neurotoxicity, and was a potent inhibitor of tumor growth in a variety of xenograft nude mouse models.?ON01910 showed strong synergy with several chemotherapeutic agents, often inducing complete regression of tumors[1].
Alias(E/Z) ON-01910 sodium
Chemical Properties
Molecular Weight473.47
FormulaC21H24NNaO8S
Cas No.1225497-78-8
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 94 mg/mL (198.53 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.1121 mL10.5603 mL21.1207 mL105.6033 mL
5 mM0.4224 mL2.1121 mL4.2241 mL21.1207 mL
10 mM0.2112 mL1.0560 mL2.1121 mL10.5603 mL
20 mM0.1056 mL0.5280 mL1.0560 mL5.2802 mL
50 mM0.0422 mL0.2112 mL0.4224 mL2.1121 mL
100 mM0.0211 mL0.1056 mL0.2112 mL1.0560 mL

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