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Ophiopogonin D'

Catalog No. TN1071 CAS 65604-80-0

Ophiopogonin D' can activate SIRT1 in a dose-dependent manner. Ophiopogonin D' also noncompetitively inhibits UGT1A6 and UGT1A10.

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Ophiopogonin D', CAS 65604-80-0

Pack Size	Availability	Price/USD
1 mg	In stock	$ 196.00
5 mg	In stock	$ 425.00
10 mg	In stock	$ 618.00
25 mg	In stock	$ 962.00
50 mg	In stock	$ 1,290.00
100 mg	In stock	$ 1,750.00
1 mL * 10 mM (in DMSO)	In stock	$ 786.00

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Purity: 99.13%

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Description	Ophiopogonin D' can activate SIRT1 in a dose-dependent manner. Ophiopogonin D' also noncompetitively inhibits UGT1A6 and UGT1A10.
In vitro	In vitro incubation system to model UGT reaction was used. Recombinant UGT isoforms-catalyzed 4-methylumbelliferone (4-MU) glucuronidation and UGT1A4-catalyzed trifluoperazine (TFP) glucuronidation reactions were employed to phenotype the inhibition profile of maidong's components towards the activity of UGT isoforms. Different inhibition potential of maidong's components towards various UGT isoforms was observed. Based on the inhibition kinetic investigation results, ophiopogonin D (OD) noncompetitively inhibited UGT1A6 and competitively inhibited UGT1A8, Ophiopogonin D' (OD') noncompetitively inhibited UGT1A6 and UGT1A10, and ruscorectal (RU) exhibited competitive inhibition towards UGT1A4. The inhibition kinetic parameters were calculated to be 20.6, 40.1, 5.3, 9.0, and 0.02 μM, respectively[1].
Source	Natural Products > Liliaceae > Ophiopogon

Molecular Weight	855.02
Formula	C44H70O16
CAS No.	65604-80-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 8.55 mg/mL (10 mM)

References and Literature

1. The Inhibition of the Components from Shengmai Injection towards UDP-Glucuronosyltransferase.Evid Based Complement Alternat Med. 2014;2014:594354. 2. Wang L , et al. Homo-aro-cholestane, furostane and spirostane saponins from the tubers of Ophiopogonjaponicus. Phytochemistry. 2017 Apr;136:125-132. 3. Wang Y, et al. Specific Turn-On Fluorescent Probe with Aggregation-Induced EmissionCharacteristics for SIRT1 Modulator Screening and Living-Cell Imaging. Anal Chem. 2015;87(10):5046-9.

Related compound libraries

This product is contained In the following compound libraries：

Natural Product Library for HTS Bioactive Compounds Library Max Natural Product Library Anti-Aging Compound Library Epigenetics Compound Library Bioactive Compound Library Metabolism Compound Library Traditional Chinese Medicine Monomer Library Anti-COVID-19 Traditional Chinese Medicine Compound Library Anti-Cancer Compound Library

Related Products

Related compounds with same targets

Dihydrocoumarin SRT1720 hydrochloride Z26395438 SIRT1 activator 1 Thiomyristoyl SIRT6-IN-3 MC3482 AGK7

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Keywords

Ophiopogonin D' 65604-80-0 Chromatin/Epigenetic DNA Damage/DNA Repair Metabolism Sirtuin UGT inhibit Inhibitor inhibitor

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