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PDK1-IN-RS2

Catalog No. T16450Cas No. 1643958-89-7

PDK1-IN-RS2 inhibits the activation of the downstream kinases S6K1 by PDK1. PDK1-IN-RS2 is a mimic of the peptide docking motif (PIFtide) and is a substrate-selective PDK1 inhibitor (Kd: 9 μM).

PDK1-IN-RS2

PDK1-IN-RS2

Catalog No. T16450Cas No. 1643958-89-7
PDK1-IN-RS2 inhibits the activation of the downstream kinases S6K1 by PDK1. PDK1-IN-RS2 is a mimic of the peptide docking motif (PIFtide) and is a substrate-selective PDK1 inhibitor (Kd: 9 μM).
Pack SizePriceAvailabilityQuantity
1 mL x 10 mM (in DMSO)$1837-10 days
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Product Introduction

Bioactivity
Description
PDK1-IN-RS2 inhibits the activation of the downstream kinases S6K1 by PDK1. PDK1-IN-RS2 is a mimic of the peptide docking motif (PIFtide) and is a substrate-selective PDK1 inhibitor (Kd: 9 μM).
Targets&IC50
PDK1:(kd)9 μM
In vitro
Because the sulfonamide is likely ionized under the crystallization conditions, the sulfonyl group of PDK1-IN-RS2 interacts with Arg131 through a salt bridge. PDK1-IN-RS2 stimulates the catalytic activity of PDK1 toward a peptide substrate by sixfold [1].
Chemical Properties
Molecular Weight380.89
FormulaC15H9ClN2O2S3
Cas No.1643958-89-7
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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