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PDK1-IN-RS2 inhibits the activation of the downstream kinases S6K1 by PDK1. PDK1-IN-RS2 is a mimic of the peptide docking motif (PIFtide) and is a substrate-selective PDK1 inhibitor (Kd: 9 μM).
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mL x 10 mM (in DMSO) | $183 | 7-10 days |
Description | PDK1-IN-RS2 inhibits the activation of the downstream kinases S6K1 by PDK1. PDK1-IN-RS2 is a mimic of the peptide docking motif (PIFtide) and is a substrate-selective PDK1 inhibitor (Kd: 9 μM). |
Targets&IC50 | PDK1:(kd)9 μM |
In vitro | Because the sulfonamide is likely ionized under the crystallization conditions, the sulfonyl group of PDK1-IN-RS2 interacts with Arg131 through a salt bridge. PDK1-IN-RS2 stimulates the catalytic activity of PDK1 toward a peptide substrate by sixfold [1]. |
Molecular Weight | 380.89 |
Formula | C15H9ClN2O2S3 |
Cas No. | 1643958-89-7 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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