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PHT-427

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Purity:100%

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COA HPLC HNMR

PHT-427

Catalog No. T2420Cas No. 1191951-57-1

PHT-427 (CS-0223) is a dual Akt (Ki: 2.7 μM) and PDPK1 (Ki: 5.2 μM) inhibitor (high-affinity binding for the PH domains of Akt and PDPK1).

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Pack Size	Price	Availability
10 mg	$39	In Stock
25 mg	$79	In Stock
50 mg	$155	In Stock
100 mg	$263	In Stock
200 mg	$452	In Stock
1 mL x 10 mM (in DMSO)	$43	In Stock

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Product Introduction

Bioactivity

Description	PHT-427 (CS-0223) is a dual Akt (Ki: 2.7 μM) and PDPK1 (Ki: 5.2 μM) inhibitor (high-affinity binding for the PH domains of Akt and PDPK1).
Targets&IC50	Akt:2.7 μM(Ki), PDK1:5.2 μM(Ki)
Kinase Assay	Surface plasmon resonance (SPR) spectroscopy binding assays: All interaction analyses are performed with a Biacore 2000, Biacore 2000 Control Software v3.2, and BIAevaluation v4.1 analysis software. The PH domain GST-fusion proteins (Akt1, IRS1, and PDK1) are immobilized on a CM5 Sensorchip using Biacore's Amine Coupling Kit to a level of 10,000 Response units (RUs). Small molecule analytes at concentrations ranging from 0.1 to 10 × the predicted KD are injected at a high flow rate (30μL/min). DMSO concentrations in all samples and running buffer are 1% (v/v) or less.
Alias	PHT 427, CS-0223

Chemical Properties

Molecular Weight	409.61
Formula	C20H31N3O2S2
Cas No.	1191951-57-1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 45 mg/mL (109.86 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4413 mL	12.2067 mL	24.4135 mL	122.0673 mL
5 mM	0.4883 mL	2.4413 mL	4.8827 mL	24.4135 mL
10 mM	0.2441 mL	1.2207 mL	2.4413 mL	12.2067 mL
20 mM	0.1221 mL	0.6103 mL	1.2207 mL	6.1034 mL
50 mM	0.0488 mL	0.2441 mL	0.4883 mL	2.4413 mL
100 mM	0.0244 mL	0.1221 mL	0.2441 mL	1.2207 mL

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