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PF-03715455

Catalog No. T16477 CAS 1056164-52-3

PF-03715455 potently inhibits LPS-induced TNFα production in human whole blood (IC50=1.7 nM). PF-03715455 is an effective inhibitor of inhaled p38 MAPK. PF-03715455 displays some selectivity for p38α over p38β (respective IC50: 0.88 and 23 nM). PF-03715455 has the potential for the treatment of COPD.

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PF-03715455, CAS 1056164-52-3

Pack Size	Availability	Price/USD
25 mg	10-14 weeks	$ 2,720.00
50 mg	10-14 weeks	$ 3,580.00
100 mg	10-14 weeks	$ 4,900.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

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Description	PF-03715455 potently inhibits LPS-induced TNFα production in human whole blood (IC50=1.7 nM). PF-03715455 is an effective inhibitor of inhaled p38 MAPK. PF-03715455 displays some selectivity for p38α over p38β (respective IC50: 0.88 and 23 nM). PF-03715455 has the potential for the treatment of COPD.
Targets&IC50	p38β:23 nM, p38α:0.88 nM
In vitro	PF-03715455 is a moderate inhibitor of CYP1A2, CYP2C19, and CYP2D6. It also is an effective inhibitor of CYP's 2C9 and CYP3A4[2].
In vivo	PF-03715455 treatment displays that the Vss is 0.19 L/kg and T1/2 is 1 hour [2].

Molecular Weight	700.27
Formula	C35H34ClN7O3S2
CAS No.	1056164-52-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Norman P, et al. Investigational p38 inhibitors for the treatment of chronic obstructive pulmonary disease. Expert Opin Investig Drugs. 2015 Mar;24(3):383-92. 2. Millan DS, et al. Design and synthesis of inhaled p38 inhibitors for the treatment of chronic obstructive pulmonary disease. J Med Chem. 2011 Nov 24;54(22):7797-814.

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Keywords

PF-03715455 1056164-52-3 MAPK p38 MAPK PF03715455 PF 03715455 inhibitor inhibit

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