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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $100 | In Stock | |
5 mg | $241 | In Stock | |
10 mg | $357 | In Stock | |
25 mg | $589 | In Stock | |
50 mg | $858 | In Stock | |
100 mg | $1,180 | In Stock | |
1 mL x 10 mM (in DMSO) | $397 | In Stock |
Description | Pinostrobin chalcone, a chalcone analog isolated from the leguminous plant, Mucuna pruriens, exhibits anticancer activity with an IC50 value of 20.42±2.23 μg/mL against MDA-MB-231 and 22.51±0.42 μg/mL against the HT-29 colon cancer cell line. |
In vitro | Pinostrobin chalcone (30 μM; 3T3-L1 cells) was a more potent inhibitor of triglyceride accumulation than the positive control berberine. Gene expression studies revealed that treatment of 3T3-L1 cells with Pinostrobin chalcone lowers the expression levels of CCAAT/enhancer-binding protein α± and peroxisome proliferator activator γ2 during adipogenesis without affecting cell viability. Treatment of 3T3-L1 cells with Pinostrobin chalcone reduced the expression levels of mRNAs encoding sterol regulatory element-binding protein 1c and several lipogenic enzymes, including fatty acid synthase and stearoyl CoA desaturase-1.[1] |
Molecular Weight | 270.28 |
Formula | C16H14O4 |
Cas No. | 18956-15-5 |
Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 90.0 mg/mL (333.0 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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