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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $106 | In Stock | |
5 mg | $247 | In Stock | |
10 mg | $363 | In Stock | |
25 mg | $591 | In Stock | |
50 mg | $793 | In Stock | |
100 mg | $1,090 | In Stock | |
500 mg | $2,190 | In Stock | |
1 mL x 10 mM (in DMSO) | $228 | In Stock |
Description | RH01386 is a small molecule that prevents ER stress-induced β cell dysfunction and death, inhibits proapoptotic gene expression, and restores ER stress-impaired glucose-stimulated insulin secretion responses, showing potential for type 2 diabetes treatment. |
In vitro | ATP levels in βTC6 cells treated with (tunicamycin) Tm increase by RH01386.RH01386 exhibits a EC50 value of 1.894 μM. RH01386 dose-dependently inhibits (tunicamycin) Tm-induced cell death, and inhibits the activity of caspase-3, a downstream effector of the apoptotic pathway in βTC6 cells. |
Molecular Weight | 424.4 |
Formula | C18H15F3N4O3S |
Cas No. | 301177-36-6 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 55 mg/mL (129.59 mM) ![]() | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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