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RH01386

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Purity:99.82%

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COA FNMR LCMS HPLC HNMR

RH01386

Catalog No. T13867Cas No. 301177-36-6

RH01386 is a small molecule that prevents ER stress-induced β cell dysfunction and death, inhibits proapoptotic gene expression, and restores ER stress-impaired glucose-stimulated insulin secretion responses, showing potential for type 2 diabetes treatment.

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Pack Size	Price	Availability
1 mg	$106	In Stock
5 mg	$247	In Stock
10 mg	$363	In Stock
25 mg	$591	In Stock
50 mg	$793	In Stock
100 mg	$1,090	In Stock
500 mg	$2,190	In Stock
1 mL x 10 mM (in DMSO)	$228	In Stock

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Product Introduction

Bioactivity

Description	RH01386 is a small molecule that prevents ER stress-induced β cell dysfunction and death, inhibits proapoptotic gene expression, and restores ER stress-impaired glucose-stimulated insulin secretion responses, showing potential for type 2 diabetes treatment.
In vitro	ATP levels in βTC6 cells treated with (tunicamycin) Tm increase by RH01386.RH01386 exhibits a EC50 value of 1.894 μM. RH01386 dose-dependently inhibits (tunicamycin) Tm-induced cell death, and inhibits the activity of caspase-3, a downstream effector of the apoptotic pathway in βTC6 cells.

Chemical Properties

Molecular Weight	424.4
Formula	C18H15F3N4O3S
Cas No.	301177-36-6

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 55 mg/mL (129.59 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3563 mL	11.7813 mL	23.5627 mL	117.8134 mL
5 mM	0.4713 mL	2.3563 mL	4.7125 mL	23.5627 mL
10 mM	0.2356 mL	1.1781 mL	2.3563 mL	11.7813 mL
20 mM	0.1178 mL	0.5891 mL	1.1781 mL	5.8907 mL
50 mM	0.0471 mL	0.2356 mL	0.4713 mL	2.3563 mL
100 mM	0.0236 mL	0.1178 mL	0.2356 mL	1.1781 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

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Keywords

RH 01386RH01386βTC6 cellsinhibitApoptosisRH-01386Inhibitortype 2 diabetesβ cell