Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ro 8-4304 Hydrochloride is an antagonist of NMDA receptor with IC50 of 0.4 μM
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 6-8 weeks | $ 681.00 |
Description | Ro 8-4304 Hydrochloride is an antagonist of NMDA receptor with IC50 of 0.4 μM |
Targets&IC50 | NMDA:0.4 μM |
In vitro | Ro 8-4304 is a voltage-independent, non-competitive antagonist of NMDA receptors in rat cultured cortical neurones and exhibits a state-dependent mode of action similar to that described for ifenprodil.?The apparent affinity of Ro 8-4304 for the NMDA receptor increased in an NMDA concentration-dependent manner so that Ro 8-4304 inhibited 10 and 100 microM NMDA responses with IC50s of 2.3 and 0.36 microM, respectively.?Currents elicited by 1 microM NMDA were slightly potentiated in the presence of 10 microM Ro 8-4304, and Ro 8-4304 binding slowed the rate of glutamate dissociation from NMDA receptors |
Synonyms | Ro 8-4304 Hydrochloride |
Molecular Weight | 370.42 |
Formula | C21H23FN2O3 |
CAS No. | 195988-65-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Ro 8-4304 195988-65-9 Neuroscience NMDAR Ro 8-4304 Hydrochloride Ro 84304 Ro 8 4304 inhibitor inhibit