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Rp-cAMPS triethylammonium salt
Rp-cAMPS triethylammonium salt is an analog of cAMP.It acts as a potent, competitive and cell-permeable antagonist of cAMP-induced activation of cAMP-dependent PKA I and II with Kis of 6.05 μM and 9.75 μM, respectively.
Catalog No. T12764Cas No. 151837-09-1
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Rp-cAMPS triethylammonium salt
Catalog No. T12764Cas No. 151837-09-1
Rp-cAMPS triethylammonium salt is an analog of cAMP.It acts as a potent, competitive and cell-permeable antagonist of cAMP-induced activation of cAMP-dependent PKA I and II with Kis of 6.05 μM and 9.75 μM, respectively.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 500 μg | $398 | 35 days | |
| 1 mg | $508 | 35 days | |
| 5 mg | $1,750 | 35 days |
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Bioactivity
Chemical Properties
| Description | Rp-cAMPS triethylammonium salt is an analog of cAMP.It acts as a potent, competitive and cell-permeable antagonist of cAMP-induced activation of cAMP-dependent PKA I and II with Kis of 6.05 µM and 9.75 µM, respectively. |
| Targets&IC50 | PKA I:ki： 6.05 µM , PKA II:9.75 µM (ki) |
| In vitro | A membrane-permeable competitive antagonist of cAMP that blocks PKA activation by binding to the regulatory subunits without dissociating the kinase holoenzyme inhibits synaptic plasticity[1]. |
| In vivo | The monosynaptic excitatory postsynaptic currents (EPSCs) induced at the PB-CeLC and BLA-CeLC synapses in tissue slices from arthritic rats were significantly reduced following treatment with Rp-cAMPS (10 μM, 15 min), whereas no reduction was observed in control neurons from healthy animals. This decline in EPSCs due to Rp-cAMPS is notably substantial when compared to the predrug artificial cerebrospinal fluid (ACSF) baseline levels measured in the identical neurons[1]. |
| Molecular Weight | 446.46 |
| Formula | C16H27N6O5PS |
| Cas No. | 151837-09-1 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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