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Rp-cAMPS sodium

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Catalog No. T36679Cas No. 142439-94-9

Rp-cAMPS sodium is a phosphorothioate analog of cAMP, a protein kinase A inhibitor and a membrane-permeable cAMP antagonist that inhibits cAMP-dependent protein kinases by blocking cAMP-induced conformational transitions, and can be used in the study of cardiovascular diseases.

Rp-cAMPS sodium

Rp-cAMPS sodium

🥰Excellent
Purity: 99.71%
Catalog No. T36679Cas No. 142439-94-9
Rp-cAMPS sodium is a phosphorothioate analog of cAMP, a protein kinase A inhibitor and a membrane-permeable cAMP antagonist that inhibits cAMP-dependent protein kinases by blocking cAMP-induced conformational transitions, and can be used in the study of cardiovascular diseases.
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1 mg$299In Stock
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Purity:99.71%
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Product Introduction

Bioactivity
Description
Rp-cAMPS sodium is a phosphorothioate analog of cAMP, a protein kinase A inhibitor and a membrane-permeable cAMP antagonist that inhibits cAMP-dependent protein kinases by blocking cAMP-induced conformational transitions, and can be used in the study of cardiovascular diseases.
Targets&IC50
PKA II:9.75 µM (Ki), PKA I:6.05 µM (Ki)
In vitro
METHODS: To measure the inhibitory effect of Rp-cAMPS sodium on purified type II cAMP-dependent protein kinase, different concentrations of Rp-cAMPS sodium were added, and their impact on cAMP-induced phosphotransferase activity was observed.
RESULTS: Rp-cAMPS sodium binds to cAMP but does not cause enzyme dissociation, thereby inhibiting the activity of the phosphotransferase[2].
In vivo
METHODS: To investigate the effect of Rp-cAMPS sodium on synaptic transmission in a rat arthritis model, particularly its modulation of PB-CeLC and BLA-CelC synapses, EPSCs were evoked by stimulating the PB-CeLC and BLA-CelC synapses, and the changes before and after treatment were compared.
RESULTS: Treatment with Rp-cAMPS sodium (10 μM, 15 minutes) significantly reduced the evoked single-synaptic EPSCs at the PB-CeLC and BLA-CelC synapses [2].
Chemical Properties
Molecular Weight367.25
FormulaC10H11N5NaO5PS
Cas No.142439-94-9
SmilesO[C@H]1[C@@H](O[C@@]2([H])[C@@]1([H])OP([S-])(OC2)=O)N3C4=NC=NC(N)=C4N=C3.[Na+]
Storage & Solubility Information
Storagestore at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
H2O: 80 mg/mL (544.59 mM), Sonication is recommended.
Solution Preparation Table
H2O
1mg5mg10mg50mg
1 mM2.7229 mL13.6147 mL27.2294 mL136.1470 mL
5 mM0.5446 mL2.7229 mL5.4459 mL27.2294 mL
10 mM0.2723 mL1.3615 mL2.7229 mL13.6147 mL
20 mM0.1361 mL0.6807 mL1.3615 mL6.8074 mL
50 mM0.0545 mL0.2723 mL0.5446 mL2.7229 mL
100 mM0.0272 mL0.1361 mL0.2723 mL1.3615 mL

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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