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Rp-cAMPS triethylammonium salt
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Catalog No. T12764Cas No. 151837-09-1
Rp-cAMPS triethylammonium salt is a competitive inhibitor of cAMP-dependent protein kinases I and II, inhibiting cAMP-induced conformational changes to block PKA activation.
Rp-cAMPS triethylammonium salt
😃Good
Catalog No. T12764Cas No. 151837-09-1
Rp-cAMPS triethylammonium salt is a competitive inhibitor of cAMP-dependent protein kinases I and II, inhibiting cAMP-induced conformational changes to block PKA activation.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 500 μg | $289 | 35 days | |
| 1 mg | $489 | 35 days | |
| 5 mg | $2,058 | 35 days |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Rp-cAMPS triethylammonium salt is a competitive inhibitor of cAMP-dependent protein kinases I and II, inhibiting cAMP-induced conformational changes to block PKA activation. |
| Targets&IC50 | PKA I:12.5 µM (Ki), PKA II:4.5 µM (Ki) |
| In vitro | Rp-cAMPS triethylammonium salt inhibits CAMP-induced CAMP-dependent protein kinase I and II activation with Ki values of 12.5 µM and 4.5 µM. Rp-cAMPS triethylammonium salt (100 μM) reduced K+ current induced by calcitonin gene-related peptide (CGRP) in porcine smooth muscle cells. [2] |
| In vivo | Rp-cAMPS triethylammonium salt (10 μM, 15 min) reduced monosynaptic EPSCs of PB-CeLC and BLA-CeLC synapses in arthritic rats, but had no effect on control neurons in normal animals. [1] Intrabla infusion of Rp-cAMPS triethylammonium salt after cocaine memory reconsolidation impaired subsequent cocaine-seeking behavior in a dose-dependent, site-specific, and memory-reactivation dependent manner. [3] |
| Molecular Weight | 446.46 |
| Formula | C16H27N6O5PS |
| Cas No. | 151837-09-1 |
| Smiles | N(CC)(CC)CC.O[C@H]1[C@H](N2C=3C(N=C2)=C(N)N=CN3)O[C@]4([C@]1(OP(=O)(S)OC4)[H])[H] |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
| Solubility Information | DMSO: 8 mg/mL (17.92 mM), Sonication is recommended. | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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