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Rp-cAMPS triethylammonium salt

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Catalog No. T12764Cas No. 151837-09-1

Rp-cAMPS triethylammonium salt is an analog of cAMP.It acts as a potent, competitive and cell-permeable antagonist of cAMP-induced activation of cAMP-dependent PKA I and II with Kis of 6.05 μM and 9.75 μM, respectively.

Rp-cAMPS triethylammonium salt
Other Forms of Rp-cAMPS triethylammonium salt:

Rp-cAMPS triethylammonium salt

😃Good
Catalog No. T12764Cas No. 151837-09-1
Rp-cAMPS triethylammonium salt is an analog of cAMP.It acts as a potent, competitive and cell-permeable antagonist of cAMP-induced activation of cAMP-dependent PKA I and II with Kis of 6.05 μM and 9.75 μM, respectively.
Pack SizePriceAvailabilityQuantity
500 μg$28935 days
1 mg$48935 days
5 mg$2,058In Stock
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Product Introduction

Bioactivity
Description
Rp-cAMPS triethylammonium salt is an analog of cAMP.It acts as a potent, competitive and cell-permeable antagonist of cAMP-induced activation of cAMP-dependent PKA I and II with Kis of 6.05 µM and 9.75 µM, respectively.
Targets&IC50
PKA II:9.75 µM (ki), PKA I:ki： 6.05 µM
In vitro
A membrane-permeable competitive antagonist of cAMP that blocks PKA activation by binding to the regulatory subunits without dissociating the kinase holoenzyme inhibits synaptic plasticity[1].
In vivo
The monosynaptic excitatory postsynaptic currents (EPSCs) induced at the PB-CeLC and BLA-CeLC synapses in tissue slices from arthritic rats were significantly reduced following treatment with Rp-cAMPS (10 μM, 15 min), whereas no reduction was observed in control neurons from healthy animals. This decline in EPSCs due to Rp-cAMPS is notably substantial when compared to the predrug artificial cerebrospinal fluid (ACSF) baseline levels measured in the identical neurons[1].
Chemical Properties
Molecular Weight446.46
FormulaC16H27N6O5PS
Cas No.151837-09-1
Relative Density.no data available
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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Keywords

RpcAMPS triethylammonium saltRp-cAMPS triethylammoniumRp cAMPS triethylammonium saltPKA IIPKA I
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