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S130
😃Good
Catalog No. T12819Cas No. 1160852-22-1
S130 is a high affinity, selectiveATG4B (a major cysteine protease) inhibitor (IC50 of 3.24 μM).It suppresses autophagy flux.
S130
😃Good
Catalog No. T12819Cas No. 1160852-22-1
S130 is a high affinity, selectiveATG4B (a major cysteine protease) inhibitor (IC50 of 3.24 μM).It suppresses autophagy flux.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $297 | 6-8 weeks | |
| 25 mg | $987 | 6-8 weeks | |
| 50 mg | $1,360 | 6-8 weeks | |
| 100 mg | $1,860 | 6-8 weeks | |
| 1 mL x 10 mM (in DMSO) | $318 | 6-8 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | S130 is a high affinity, selectiveATG4B (a major cysteine protease) inhibitor (IC50 of 3.24 μM).It suppresses autophagy flux. |
| Targets&IC50 | ATG4B:3.24 µM |
| In vitro | S130 suppresses autophagy and activates apoptosis by inhibiting ATG4B, leading to enhanced cytotoxicity. S130 (0-25 μM; 48 hours) induces cell death through ATG4B inhibition at doses higher than 6.3 μM, without causing necroptosis. Nutrient deprivation enhances S130-induced cytotoxicity. S130 (0-10 μM; 24 hours) suppresses approximately 79% of full-length LC3-GST cleavage at 10 μM, while no substrates were processed in ATG4B KO cells. S130 exhibits significant inhibitory effects on ATG4B. |
| In vivo | Tumor growth suppressed by S130 (20 mg/kg; i.p.; daily; 3 weeks), S130 shows an efficient in vivo antitumor effect with a sound safety on vital organs. |
| Molecular Weight | 387.47 |
| Formula | C24H25N3O2 |
| Cas No. | 1160852-22-1 |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 125 mg/mL (322.61 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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