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KGP94

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Purity:98.52%

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COA HNMR LCMS

KGP94

Catalog No. T27730Cas No. 1131456-28-4

KGP94 is a potent, selective, and competitive inhibitor of the lysosomal endopeptidase enzyme.

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Pack Size	Price	Availability
1 mg	$115	In Stock
5 mg	$247	In Stock
10 mg	$397	In Stock
25 mg	$663	In Stock
50 mg	$945	In Stock
100 mg	$1,280	In Stock
500 mg	$2,570	In Stock
1 mL x 10 mM (in DMSO)	$272	In Stock

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Product Introduction

Bioactivity

Description	KGP94 is an inhibitor of cysteine protease Cathepsin L(CTSL).
In vitro	The novel cathepsin L/K inhibitors KGP94 could inhibit in vitro M2 macrophage invasion and reduce the macrophage-stimulated invasion of 4T1 murine breast cancer cells. KGP94 treatment also reduced the expression of several M2-associated markers, suggesting that cathepsin L activity may be important for IL-4-driven M0 to M2 differentiation[1].
Alias	KGP-94, KGP 94

Chemical Properties

Molecular Weight	350.23
Formula	C14H12BrN3OS
Cas No.	1131456-28-4

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 60 mg/ml (171.32 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8553 mL	14.2763 mL	28.5527 mL	142.7633 mL
5 mM	0.5711 mL	2.8553 mL	5.7105 mL	28.5527 mL
10 mM	0.2855 mL	1.4276 mL	2.8553 mL	14.2763 mL
20 mM	0.1428 mL	0.7138 mL	1.4276 mL	7.1382 mL
50 mM	0.0571 mL	0.2855 mL	0.5711 mL	2.8553 mL
100 mM	0.0286 mL	0.1428 mL	0.2855 mL	1.4276 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc