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SB-399885 hydrochloride

Catalog No. T12843Cas No. 402713-81-9

SB-399885 hydrochloride is an antagonist of 5-HT6 receptor.

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Product Introduction

Bioactivity

Description

SB-399885 hydrochloride is an antagonist of 5-HT6 receptor.

In vivo

SB-399885 hydrochloride, administered at a dose of 10 mg/kg, significantly enhances wakefulness (W) (F(3,15)=3.32, P<0.05) and decreases both slow wave sleep (SWS) and rapid-eye-movement sleep (REMS), as well as reducing the number of REM periods (F(3,15)=4.0, P<0.01; F(3,15)=3.14, P<0.05 and F(3,15)=2.62, P<0.05, respectively) compared to the control vehicle. Further analysis on 2-hour intervals revealed that this dose increased W (F(3,15)=5.48, P<0.01) and diminished SWS and REMS during the initial 2-hour period (F(3,15)=5.42, P<0.01 and F(3,15)= 4.05, P<0.01, respectively). Additionally, doses of 5 and 10 mg/kg were found to increase light sleep across the first and second 2-hour recording periods (F(3,15)=3.46,P<0.01 and F(3,15)= 3.65, P<0.01; and F(3,15)=3.23, P<0.05 and F(3,15)=3.08, P<0.05, respectively). The 10 mg/kg dose also notably prolonged REMS latency (F(3,15)=3.60, P<0.01) and decreased the number of REM periods within the first two hours of recording (F(3,15)=3.88, P<0.01).

Chemical Properties

Molecular Weight	482.81
Formula	C18H22Cl3N3O4S
Cas No.	402713-81-9

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 125 mg/mL (258.90 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0712 mL	10.3560 mL	20.7121 mL	103.5604 mL
5 mM	0.4142 mL	2.0712 mL	4.1424 mL	20.7121 mL
10 mM	0.2071 mL	1.0356 mL	2.0712 mL	10.3560 mL
20 mM	0.1036 mL	0.5178 mL	1.0356 mL	5.1780 mL
50 mM	0.0414 mL	0.2071 mL	0.4142 mL	2.0712 mL
100 mM	0.0207 mL	0.1036 mL	0.2071 mL	1.0356 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

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