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Pack Size | Price | Availability | Quantity |
---|---|---|---|
500 mg | $89 | In Stock |
Description | Desvenlafaxine (O-Desmethylvenlafaxine) is a cyclohexanol and phenol derivative and metabolite of venlafaxine that functions as a serotonin and noradrenaline reuptake inhibitor (SNRI) and is used as an antidepressive agent. |
Targets&IC50 | 5-HT:40.2 nM(Ki), Norepinephrine:558.4 nM(Ki) |
In vitro | In male rats, the oral administration of Desvenlafaxine Succinate penetrates the brain and hypothalamus, significantly increasing extracellular norepinephrine levels. |
In vivo | Desvenlafaxine Succinate inhibits the neuronal uptake of serotonin (5-HT) and norepinephrine (NE) with IC50 values of 47.3 nM and 531.3 nM, respectively. It exhibits weak binding affinity to human dopamine (DA) transporters at a concentration of 100 μM. |
Alias | WY 45233 Succinate, O-Desmethylvenlafaxine |
Molecular Weight | 263.38 |
Formula | C16H25NO2 |
Cas No. | 93413-62-8 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | Ethanol: 3 mg/mL (11.39 mM) DMSO: 16.67 mg/mL (63.28 mM), Sonication is recommended. ![]() | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
Ethanol/DMSO
DMSO
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