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Senecionine

Catalog No. TQ0192 CAS 130-01-8

Synonyms: Aureine, Senecionan-11,16-dione, 12-hydroxy-, Senecionin

Senecionine (Senecionin) is the hepatotoxic pyrrolizidine alkaloids isolated from Senecio vulgaris.

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Senecionine, CAS 130-01-8

Pack Size	Availability	Price/USD
1 mg	In stock	$ 68.00
5 mg	In stock	$ 196.00
10 mg	In stock	$ 295.00
25 mg	In stock	$ 497.00
50 mg	In stock	$ 723.00
100 mg	In stock	$ 987.00
1 mL * 10 mM (in DMSO)	In stock	$ 198.00

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Purity: 98.82%

Purity: 97.8%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Senecionine (Senecionin) is the hepatotoxic pyrrolizidine alkaloids isolated from Senecio vulgaris.
In vitro	The cytotoxicity was greater in the absence of extracellular Ca2+ than in its presence, suggesting that alterations in intracellular Ca2+ distribution, and not an influx of extracellular Ca2+, were responsible for the Senecionine-induced hepatotoxicity [1].
In vivo	Senecionine fails to stimulate epoxide hydrase, it diminishes the activity of glutathione-s-transferase, aminopyrine demethylase and AHH [2]. Twice-weekly injections of senecionine, beginning on Day 12 or later, results in premature deliveries in three of seven rats, and the pups from all litters are stillborn or die shortly after birth [3].
Animal Research	Swiss albino rats weighing 155-175 g are incubated for 3 consecutive days with seneciphylline and senecionine at a daily dose of 40 or 80 mg/kg body wt. Control animals received normal saline only. The animals are killed 24 h after the last dose. The livers are removed, weighed and then homogenized in 1.15% KCI, 0.02 HEPES (pH 7.4) [4].
Source	Natural Products > Asteraceae > Senecio

Synonyms	Aureine, Senecionan-11,16-dione, 12-hydroxy-, Senecionin
Molecular Weight	335.39
Formula	C18H25NO5
CAS No.	130-01-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 1 mg/mL (2.98 mM)

DMSO: 5 mg/mL (14.91 mM)

References and Literature

1. D S Griffin, et al. Effects of the Pyrrolizidine Alkaloid Senecionine and the Alkenals trans-4-OH-hexenal and trans-2-hexenal on Intracellular Calcium Compartmentation in Isolated Hepatocytes. Biochem Pharmacol. 1989 Feb 1; 38 (3), 391-7 2. Kakrani HK, et al. Effect of seneciphylline and senecionine on hepatic drug metabolizing enzymes in rats. J Ethnopharmacol. 1984 Dec;12(3):271-8. 3. Tu ZB, et al. Identification of senecionine and senecionine N-oxide as antifertility constituents in Senecio vulgaris. J Pharm Sci. 1988 May;77(5):461-3. 4. Wang C, et al. The comparative pharmacokinetics of two pyrrolizidine alkaloids, senecionine and adonifoline, and their main metabolites in rats after intravenous and oral administration by UPLC/ESIMS. Anal Bioanal Chem. 2011 Jul;401(1):275-87.

Related compound libraries

This product is contained In the following compound libraries：

Covalent Inhibitor Library PBCRBS Traditional Chinese Medicine Compound Library Natural Product Library Traditional Mongolian Medicine Compound Library Natural Product Library for HTS Alkaloid Natural Product Library Selected Plant-Sourced Compound Library Chinese Pharmacopoeia Natural Product Library Anti-Tumor Natural Product Library Traditional Chinese Medicine Monomer Library

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Keywords

Senecionine 130-01-8 Others Inhibitor Aureine Senecionan-11,16-dione, 12-hydroxy- Senecionin inhibit inhibitor

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