Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Siramesine (Lu 28-179)(Lu 28-179) is a selective sigma-2 receptor agonist, which has been shown to trigger cell death of cancer cells and to exhibit a potent anticancer activity in vivo.lysosome-destabilizing agent siramesine can induce rapid cell death in a number of cell lines at concentrations above 20 μM. In HaCaT cells, cell death was accompanied by caspase activation, rapid loss of mitochondrial membrane potential (MMP), cytochrome c release, cardiolipin peroxidation and typical apoptotic morphology, whereas in U-87MG cells most apoptotic hallmarks were not notable, although MMP was rapidly lost
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | 4-6 weeks | $ 207.00 | |
10 mg | 4-6 weeks | $ 314.00 | |
25 mg | 4-6 weeks | $ 479.00 | |
50 mg | 4-6 weeks | $ 738.00 |
Description | Siramesine (Lu 28-179)(Lu 28-179) is a selective sigma-2 receptor agonist, which has been shown to trigger cell death of cancer cells and to exhibit a potent anticancer activity in vivo.lysosome-destabilizing agent siramesine can induce rapid cell death in a number of cell lines at concentrations above 20 μM. In HaCaT cells, cell death was accompanied by caspase activation, rapid loss of mitochondrial membrane potential (MMP), cytochrome c release, cardiolipin peroxidation and typical apoptotic morphology, whereas in U-87MG cells most apoptotic hallmarks were not notable, although MMP was rapidly lost |
In vivo | SA4503 or siramesine given jointly with MEM (as well as with AMA) decreased the immobility time in rats. The effect of SA4503 and AMA co-administration was antagonized by progesterone, a sigma1 receptor antagonistic neurosteroid. |
Synonyms | Lu 28-179 |
Molecular Weight | 454.58 |
Formula | C30H31FN2O |
CAS No. | 147817-50-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Siramesine 147817-50-3 GPCR/G Protein Sigma receptor Inhibitor lysosomes inhibit death cathepsin Sigma Receptor mitochondria selectivity Lu 28-179 cancer inhibitor