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Blarcamesine hydrochloride
🥰Excellent
Catalog No. T4111Cas No. 195615-84-0
Alias AVex-73 hydrochloride, Anavex 2-73, AE-37 hydrochloride
Blarcamesine hydrochloride (AVex-73 hydrochloride) is a Sigma-1 Receptor agonist (IC50: 860 nM).
Blarcamesine hydrochloride
🥰Excellent
Purity: 99.95%
Catalog No. T4111Alias AVex-73 hydrochloride, Anavex 2-73, AE-37 hydrochlorideCas No. 195615-84-0
Blarcamesine hydrochloride (AVex-73 hydrochloride) is a Sigma-1 Receptor agonist (IC50: 860 nM).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $38 | In Stock | |
| 2 mg | $54 | In Stock | |
| 5 mg | $85 | In Stock | |
| 10 mg | $142 | In Stock | |
| 25 mg | $269 | In Stock | |
| 50 mg | $482 | In Stock | |
| 100 mg | $689 | In Stock | |
| 500 mg | $1,480 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $98 | In Stock |
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Purity:99.95%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Blarcamesine hydrochloride (AVex-73 hydrochloride) is a Sigma-1 Receptor agonist (IC50: 860 nM). |
| Targets&IC50 | σ1:860 nM |
| In vivo | The pretreatment of Blarcamesine(1/3 mg/kg) dose-dependently reduces the scopolamine-induced alternation deficit. The pretreatment with Blarcamesine(>0.3 mg/kg) dose-dependently and significantly attenuates the impairments of step-through latency[1]. The Blarcamesine(1mg/kg) dose-dependently blocks the recognition memory deficit. One day after injections, the significant Aβ25-35-induced decrease in Akt phosphorylation is significantly attenuated by Blarcamesine(0.1/1mg/kg). Seven days after injections, Blarcamesineattenuates the decrease in Ser9 phosphorylation induced by the peptide (0.3/1mg/kg)[2]. |
| Animal Research | Drugs (including Anavex 2-73) are solubilized in physiological saline at the concentration of 5?mg/mL.Male mice aged 7-9 weeks and weighing 32±2?g are used. Drugs (including Anavex 2-73) are brought up to each dose by dilution and injected in a volume of 100?μL/20?g body weight. Animals are used between days 1 and 9 after i.c.v. injections for behavioral testing or killed before biochemical measures. |
| Alias | AVex-73 hydrochloride, Anavex 2-73, AE-37 hydrochloride |
| Molecular Weight | 317.85 |
| Formula | C19H24ClNO |
| Cas No. | 195615-84-0 |
| Smiles | Cl.CN(C)CC1CCOC1(c1ccccc1)c1ccccc1 |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 55 mg/mL (173.04 mM)  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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