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Sigma-1 receptor antagonist 2

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Purity:99.52%

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COA HPLC HNMR

Sigma-1 receptor antagonist 2

Catalog No. T12911Cas No. 1639220-15-7

Sigma-1 receptor antagonist 2 is a more potent and selective antagonist of the sigma-1 receptor (σ1 R, Ki = 3.88 nM) compared to the sigma-2 receptor (Ki = 1288 nM).

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Pack Size	Price	Availability
1 mg	$97	In Stock
5 mg	$247	In Stock
10 mg	$413	In Stock
25 mg	$692	In Stock
50 mg	$985	In Stock
100 mg	$1,330	In Stock
500 mg	$2,660	In Stock
1 mL x 10 mM (in DMSO)	$272	In Stock

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Product Introduction

Bioactivity

Description	Sigma-1 receptor antagonist 2 is a more potent and selective antagonist of the sigma-1 receptor (σ1 R, Ki = 3.88 nM) compared to the sigma-2 receptor (Ki = 1288 nM).
Targets&IC50	σ1 receptor:3.88 nM(Ki), σ2 receptor:1288 nM(Ki)

Chemical Properties

Molecular Weight	375.89
Formula	C20H26ClN3O2
Cas No.	1639220-15-7

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 86.67 mg/mL (230.57 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6604 mL	13.3018 mL	26.6035 mL	133.0176 mL
5 mM	0.5321 mL	2.6604 mL	5.3207 mL	26.6035 mL
10 mM	0.2660 mL	1.3302 mL	2.6604 mL	13.3018 mL
20 mM	0.1330 mL	0.6651 mL	1.3302 mL	6.6509 mL
50 mM	0.0532 mL	0.2660 mL	0.5321 mL	2.6604 mL
100 mM	0.0266 mL	0.1330 mL	0.2660 mL	1.3302 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc