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S1R agonist 2
Contact us for more batch information
S1R agonist 2
Catalog No. T72059Cas No. 150085-21-5
S1R agonist 2 is a selective S1R agonist with a Ki of 88 nM for S2R and 1.1 nM for S1R and is protective against ROS and NMDA-induced neurotoxicity.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $39 | In Stock | |
| 5 mg | $93 | In Stock | |
| 10 mg | $148 | In Stock | |
| 25 mg | $287 | In Stock | |
| 50 mg | $435 | In Stock | |
| 100 mg | $643 | In Stock | |
| 500 mg | $1,360 | In Stock |
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Questions
View MoreInhibitors Related to "S1R agonist 2"
Sigma-1 receptor antagonist 2
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Sigma-1 receptor antagonist 2 is a potent and selective antagonist of sigma 1 receptor (σ1 R) (σ1 and σ2 receptor with Kis of 3.88 and 1288 nM , respectively).
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S1R agonist 1 hydrochloride
T78086242487-82-7
S1R Agonist 1 (Compound 6b) hydrochloride is a selective S1R agonist, displaying K i values of 0.93 nM for S1R and 72 nM for S2R, and has demonstrated neuroprotective effects against ROS and NMDA-induced neurotoxicity [1].
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WLB-89462
T796662849471-75-4
WLB-89462 (Compound 20c) is a selective σ2 receptor ligand with a K i of 13 nM, exhibiting neuroprotective properties and the ability to ameliorate Aβ peptide-induced short-term memory impairment in rats. It possesses a favorable ADMET profile characterized by good solubility, absence of CYP inhibition, robust metabolic stability, high permeability, effective brain penetration, and substantial oral exposure in rodent models [1].
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BD1063 dhydrochloride
Cited
T7488206996-13-6
BD1063 dhydrochloride is a potent and selective sigma 1(σ1) receptor antagonist(Ki = 9 nM).
- $41
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CitedPD 144418 oxalate
T392111794760-28-3
PD 144418 oxalate is a highly potent and selective sigma 1 (σ1) receptor ligand, displaying a Ki value of 0.08 nM for σ1 and 1377 nM for σ2. It exhibits negligible affinity for other receptors, ion channels, and enzymes. Additionally, PD 144418 oxalate demonstrates potential antipsychotic activity.
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BD 1008 dihydrobromide
T21788138356-09-9
BD 1008 dihydrobromide is a selective antagonist of the sigma 1 (σ1) receptor (Ki = 2 nM). BD 1008 dihydrobromide have high affinity for sigma1 receptors, moderate affinity for sigma2 receptors.
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NE-100 hydrochloride
T20797149409-57-4
NE-100 hydrochloride (NE-100 HCl) is a potent and selective antagonist of σ1 (IC50 = 4.16 nM) with antipsychotic activity. NE100 HCl also suppresses ER stress-induced hippocampal cell death.
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PRE-084 hydrochloride
T3198L75136-54-8
PRE-084 hydrochloride is a selective agonist of σ1(IC50:44 nM, in the sigma receptor assay).
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PD 144418
T16445154130-99-1
PD 144418 displays potential antipsychotic activity. PD 144418 is a high affinity, potent and selective sigma 1 (σ1) receptor ligand (Ki: 0.08 nM and 1377 nM for σ1 and σ2 respectively). It shows devoid of any significant affinity for other receptors, ion channels, and enzymes.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | S1R agonist 2 is a selective S1R agonist with a Ki of 88 nM for S2R and 1.1 nM for S1R and is protective against ROS and NMDA-induced neurotoxicity. |
| In vitro | S1R agonist 2 (Compound 8b; 0.1-5 μ M) Both can significantly increase the growth of Neurite induced by nerve growth factor (NGF) in a dose-dependent manner.[1] The concentration of S1R agonist 2 (24 hours) in SHSY5Y cells is 1 μ M has a significant inhibitory effect on cell damage induced by Rotenone.[1] S1R agonist 2 (0.1-5 μ M; 24 hours) Neuroprotective effect on NMDA stimulation in SHSY5Y cells.[1] S1R agonist 2 (0-10 μ M; 24-72 hours) has no cytotoxicity to A549, LoVo, and Panc-1 cells.[1] |
| Molecular Weight | 309.45 |
| Formula | C21H27NO |
| Cas No. | 150085-21-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 50 mg/mL (161.58 mM)  | |||||||||||||||||||||||||||||||||||
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