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S1R agonist 2
🥰Excellent
Catalog No. T72059Cas No. 150085-21-5
S1R agonist 2 is a selective S1R agonist with a Ki of 88 nM for S2R and 1.1 nM for S1R and is protective against ROS and NMDA-induced neurotoxicity.
S1R agonist 2
🥰Excellent
Purity: 99.04%
Catalog No. T72059Cas No. 150085-21-5
S1R agonist 2 is a selective S1R agonist with a Ki of 88 nM for S2R and 1.1 nM for S1R and is protective against ROS and NMDA-induced neurotoxicity.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $34 | In Stock | |
| 5 mg | $56 | In Stock | |
| 10 mg | $89 | In Stock | |
| 25 mg | $172 | In Stock | |
| 50 mg | $261 | In Stock | |
| 100 mg | $386 | In Stock | |
| 200 mg | $545 | In Stock |
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Purity:99.04%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | S1R agonist 2 is a selective S1R agonist with a Ki of 88 nM for S2R and 1.1 nM for S1R and is protective against ROS and NMDA-induced neurotoxicity. |
| Targets&IC50 | σ2 receptor:88 nM (Ki), σ1 receptor:1.1 nM (Ki) |
| In vitro | S1R agonist 2 (Compound 8b; 0.1-5 μM) significantly increases neurite growth induced by nerve growth factor (NGF) in a dose-dependent manner and has a neuroprotective effect on NMDA stimulation in SHSY5Y cells. At 1 μM (24 hours), it significantly inhibits cell damage induced by Rotenone in SHSY5Y cells and shows no cytotoxicity to A549, LoVo, and Panc-1 cells (0-10 μM; 24-72 hours).[1] |
| Molecular Weight | 309.45 |
| Formula | C21H27NO |
| Cas No. | 150085-21-5 |
| Smiles | C(C1CCN(CCCOC2=CC=CC=C2)CC1)C3=CC=CC=C3 |
Storage & Solubility Information
| Storage | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 50 mg/mL (161.58 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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