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S1R agonist 2 hydrochloride
Catalog No. T78087
Compound 8b hydrochloride, a selective S1R agonist, exhibits affinity with K i s of 1.1 nM for S1R and 88 nM for S2R. It demonstrates neuroprotective effects against ROS and NMDA-induced neurotoxicity [1].
S1R agonist 2 hydrochloride
S1R agonist 2 hydrochloride
Catalog No. T78087
Compound 8b hydrochloride, a selective S1R agonist, exhibits affinity with K i s of 1.1 nM for S1R and 88 nM for S2R. It demonstrates neuroprotective effects against ROS and NMDA-induced neurotoxicity [1].
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $97 | 5 days |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Compound 8b hydrochloride, a selective S1R agonist, exhibits affinity with K i s of 1.1 nM for S1R and 88 nM for S2R. It demonstrates neuroprotective effects against ROS and NMDA-induced neurotoxicity [1]. |
| In vitro | S1R agonist 2 (Compound 8b; 0.1-5 μM) hydrochloride significantly enhances NGF-induced neurite outgrowth in a dose-dependent manner; at 1 μM over 24 hours, it markedly inhibits Rotenone-induced cellular damage in SHSY5Y cells. Additionally, it offers neuroprotection against NMDA stimulation in SHSY5Y cells at 0.1-5 μM over 24 hours. This compound exhibits no cytotoxicity in A549, LoVo, and Panc-1 cells at varying concentrations (0-10 μM) and durations (24-72 h) [1]. |
| In vivo | Compound 8b (S1R agonist 2; 0.1-50 μM; 120 h) hydrochloride at a concentration of 10 μM does not induce embryonic mortality (100% survival of embryos), yet at the highest dosage (50 μM), it induces death in all embryos [1]. |
| Molecular Weight | 345.91 |
| Formula | C21H28ClNO |
Storage & Solubility Information
| Storage | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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