Shopping Cart

Remove All
Your shopping cart is currently empty

Smurf1-IN-A01

Smurf1-IN-A01 (A01) is a ubiquitin ligase Smad ubiquitination regulatory factor-1 inhibitor (Kd: 3.664 nM) that enhances BMP-2 responsiveness by preventing Smurf1-mediated Smad1/5 degradation.

Catalog No. T16904Cas No. 1007647-73-5

Select Batch

Purity:99.54%

Resource Download

COA HNMR LCMS

Smurf1-IN-A01

Catalog No. T16904Cas No. 1007647-73-5

Smurf1-IN-A01 (A01) is a ubiquitin ligase Smad ubiquitination regulatory factor-1 inhibitor (Kd: 3.664 nM) that enhances BMP-2 responsiveness by preventing Smurf1-mediated Smad1/5 degradation.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Pack Size	Price	Availability
1 mg	$32	In Stock
2 mg	$45	In Stock
5 mg	$72	In Stock
10 mg	$122	In Stock
25 mg	$247	In Stock
50 mg	$396	In Stock
100 mg	$589	In Stock
1 mL x 10 mM (in DMSO)	$82	In Stock

Bulk & Custom

Add to Cart

Questions

Related Compound Libraries of "Smurf1-IN-A01"

Product Introduction

Bioactivity

Description	Smurf1-IN-A01 (A01) is a ubiquitin ligase Smad ubiquitination regulatory factor-1 inhibitor (Kd: 3.664 nM) that enhances BMP-2 responsiveness by preventing Smurf1-mediated Smad1/5 degradation.
Targets&IC50	SMURF1:(kd)3.664 nM
Alias	A01

Chemical Properties

Molecular Weight	512.93
Formula	C₂₂H₂₀ClF₃N₄O₃S
Cas No.	1007647-73-5

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 62.5 mg/mL (121.85 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9496 mL	9.7479 mL	19.4958 mL	97.4792 mL
5 mM	0.3899 mL	1.9496 mL	3.8992 mL	19.4958 mL
10 mM	0.1950 mL	0.9748 mL	1.9496 mL	9.7479 mL
20 mM	0.0975 mL	0.4874 mL	0.9748 mL	4.8740 mL
50 mM	0.0390 mL	0.1950 mL	0.3899 mL	1.9496 mL
100 mM	0.0195 mL	0.0975 mL	0.1950 mL	0.9748 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Smurf1-IN-A01A-01InhibitorSmurf1 IN A01inhibitA 01Smurf1INA01Smurf-1-IN-A01