Shopping Cart
  • Remove All
  • TargetMol
    Your shopping cart is currently empty

Tasidotin hydrochloride

Tasidotin hydrochloride
Tasidotin hydrochloride, a peptide analog of the antimitotic depsipeptide dolastatin 15, is an inhibitor of microtubule assembly and microtubule dynamics.
Catalog No. T16997Cas No. 623174-20-9
Contact us for more batch information
Resource Download

Tasidotin hydrochloride

Catalog No. T16997Cas No. 623174-20-9
Tasidotin hydrochloride, a peptide analog of the antimitotic depsipeptide dolastatin 15, is an inhibitor of microtubule assembly and microtubule dynamics.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
100 mgInquiryBackorder
500 mgInquiryBackorder
Bulk & Custom
Add to Cart
Questions
View More

Product Introduction

Bioactivity
Description
Tasidotin hydrochloride, a peptide analog of the antimitotic depsipeptide dolastatin 15, is an inhibitor of microtubule assembly and microtubule dynamics.
In vitro
The greatest difference in sensitivity to Tasidotin is between the more sensitive MDA-MB-435 line and the less sensitive HS 578-T line of the remaining lines. The IC50 values in the two lines are 4 and 200 nM, respectively. The IC50 in Ewing's sarcoma, rhabdomyosarcoma, osteosarcoma, and synovial sarcoma lines ranges from 2 to 320 nM. Tasidotin induces a G2-M arrest that persists for 48 h after Tasidotin is washed from the cells in the SK-ES1 and RH30 cell lines. In vitro, more than half the cells are in the early or late phase of apoptosis 48 h after treatment with Tasidotin. Following treatment for 24 h with 160 nM Tasidotin, the RH30 line, and SK-ES1 line each shows an accumulation of cells in the G2-M phase. At hour 24, nearly all the RH30 cells are in the G2-M phase [1][2].
In vivo
Tasidotin (90 mg/kg/d, mice) treatment has a mean weight loss of <16% following each 5-day treatment of Tasidotin. In vivo, a significant increase in apoptotic nuclei is apparent in xenograft tumors harvested within 24 h after a 5-day course of Tasidotin. Mice treated with 100 mg/kg have a mean weight loss of >20% with no return to their baseline starting weight, and one mouse dies before the second treatment course [2].
AliasILX651
Chemical Properties
Molecular Weight643.3
FormulaC32H59ClN6O5
Cas No.623174-20-9
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Calculator

  • Molarity Calculator
  • Dilution Calculator
  • Reconstitution Calculator
  • Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
%Tween 80
%ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Related Tags: buy Tasidotin hydrochloride | purchase Tasidotin hydrochloride | Tasidotin hydrochloride cost | order Tasidotin hydrochloride | Tasidotin hydrochloride chemical structure | Tasidotin hydrochloride in vivo | Tasidotin hydrochloride in vitro | Tasidotin hydrochloride formula | Tasidotin hydrochloride molecular weight