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UNC-2170

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COA HPLC HNMR

UNC-2170

Catalog No. T24925Cas No. 1648707-58-7

UNC-2170 (UNC2170 Maleate) is the methyl-lysine binding protein, 53BP1 ligand.

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Pack Size	Price	Availability
1 mg	$48	In Stock
2 mg	$68	In Stock
5 mg	$113	In Stock
10 mg	$189	In Stock
25 mg	$413	In Stock
50 mg	$618	In Stock
100 mg	$879	In Stock
500 mg	$1,790	In Stock
1 mL x 10 mM (in DMSO)	$153	In Stock

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Product Introduction

Bioactivity

Description	UNC-2170 (UNC2170 Maleate) is the methyl-lysine binding protein, 53BP1 ligand.
In vitro	UNC-2170 (500 μM) results in a significant increase in soluble 53BP1 as compared to lysates treated with UNC2892, the negative control compound. UNC-2170 (30-100 μM; naive splenocytes cultured with LPS and IL-4 for 3.5 days) clearly phenocopies the reduction in CSR seen in 53BP1 mutant B cells[1].
Alias	UNC2170 Maleate, UNC-2170 Maleate, UNC 2170 Maleate

Chemical Properties

Molecular Weight	313.23
Formula	C14H21BrN2O
Cas No.	1648707-58-7

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 60 mg/ml (191.55 mM)

Methanol: 125 mg/mL (399.07 mM)

Solution Preparation Table

Methanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1925 mL	15.9627 mL	31.9254 mL	159.6271 mL
5 mM	0.6385 mL	3.1925 mL	6.3851 mL	31.9254 mL
10 mM	0.3193 mL	1.5963 mL	3.1925 mL	15.9627 mL
20 mM	0.1596 mL	0.7981 mL	1.5963 mL	7.9814 mL
50 mM	0.0639 mL	0.3193 mL	0.6385 mL	3.1925 mL
100 mM	0.0319 mL	0.1596 mL	0.3193 mL	1.5963 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc