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unc-2170 maleate

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  • Inhibitors & Agonists
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UNC2170 maleate
T844162173992-60-2
53BP1-binding protein 1 (53BP1) engages with dimethylated lysine 20 on histone 4 (H4K20me2) through its tandem tudor domains within a homodimer configuration, crucial for the DNA damage response. UNC2170, a micromolar 53BP1 ligand, selectively interacts with this site, demonstrating at least 17-fold preference for 53BP1 over similar proteins. This interaction occurs in a pocket formed by the 53BP1's tudor domains. Moreover, UNC2170 acts as an antagonist to 53BP1 in cellular lysates, effectively inhibiting class switch recombination, a process dependent on the functional 53BP1 tudor domain, thus confirming its cellular activity.
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8-10 weeks
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UNC-2170
UNC-2170, UNC2170, UNC 2170
T249251648707-58-7
UNC-2170 (UNC2170 Maleate) is the methyl-lysine binding protein, 53BP1 ligand.
  • $29
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