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UNC-2170

Name: UNC-2170
Brand: TargetMol
SKU: T24925
Price: 27 EUR
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T24925Cas No. 1648707-58-7

Alias UNC-2170, UNC2170, UNC 2170

UNC-2170 (UNC2170 Maleate) is the methyl-lysine binding protein, 53BP1 ligand.

UNC-2170

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Purity: 98.83%

Catalog No. T24925Alias UNC-2170, UNC2170, UNC 2170Cas No. 1648707-58-7

UNC-2170 (UNC2170 Maleate) is the methyl-lysine binding protein, 53BP1 ligand.

Pack Size	Price	Availability
1 mg	27 €	In Stock
2 mg	37 €	In Stock
5 mg	64 €	In Stock
10 mg	107 €	In Stock
25 mg	235 €	In Stock
50 mg	352 €	In Stock
100 mg	500 €	In Stock
200 mg	688 €	In Stock
1 mL x 10 mM (in DMSO)	87 €	In Stock

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Purity:98.83%

Resource Download

COA HNMR HPLC

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Product Introduction

Bioactivity

Description	UNC-2170 (UNC2170 Maleate) is the methyl-lysine binding protein, 53BP1 ligand.
In vitro	UNC-2170 (500 μM) results in a significant increase in soluble 53BP1 as compared to lysates treated with UNC2892, the negative control compound. UNC-2170 (30-100 μM; naive splenocytes cultured with LPS and IL-4 for 3.5 days) clearly phenocopies the reduction in CSR seen in 53BP1 mutant B cells[1].
Alias	UNC-2170, UNC2170, UNC 2170

Chemical Properties

Molecular Weight	313.23
Formula	C₁₄H₂₁BrN₂O
Cas No.	1648707-58-7
Smiles	CC(C)(C)NCCCNC(=O)c1cccc(Br)c1
Relative Density.	1.233 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 60 mg/ml (191.55 mM), Sonication is recommended.

Methanol: 125 mg/mL (399.07 mM), Sonication is recommended.

Solution Preparation Table

DMSO/Methanol

	1mg	5mg	10mg	50mg
1 mM	3.1925 mL	15.9627 mL	31.9254 mL	159.6271 mL
5 mM	0.6385 mL	3.1925 mL	6.3851 mL	31.9254 mL
10 mM	0.3193 mL	1.5963 mL	3.1925 mL	15.9627 mL
20 mM	0.1596 mL	0.7981 mL	1.5963 mL	7.9814 mL
50 mM	0.0639 mL	0.3193 mL	0.6385 mL	3.1925 mL
100 mM	0.0319 mL	0.1596 mL	0.3193 mL	1.5963 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

UNC-2170 MaleateUNC2170 MaleateUNC 2170 Maleatetudor domainKme readersH4K20me2double-strand DNA breaks53BP1