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VA-K-14 hydrochloride

VA-K-14 hydrochloride
VA-K-14 hydrochloride(VAK14 HCl) is a selective thyrotropin receptor (TSHR) antagonist (IC50= 12.3 μM) that inhibits TSHR stimulation by serum and monoclonal TSHR-stimulating antibodies from patients with GD and abrogates TSHR signaling.
Catalog No. T29087Cas No. 1171341-19-7
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Purity:98.01%
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VA-K-14 hydrochloride

Purity: 98.01%
Catalog No. T29087Alias VAK14 Hydrochloride, VA-K-14 HCl, VAK14 HCl, VA K 14 HClCas No. 1171341-19-7

VA-K-14 hydrochloride(VAK14 HCl) is a selective thyrotropin receptor (TSHR) antagonist (IC50= 12.3 μM) that inhibits TSHR stimulation by serum and monoclonal TSHR-stimulating antibodies from patients with GD and abrogates TSHR signaling.
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Pack SizePriceAvailabilityQuantity
1 mg$54In Stock
5 mg$127In Stock
10 mg$196In Stock
25 mg$396In Stock
50 mg$645In Stock
100 mg$987In Stock
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Product Introduction

Bioactivity
Description
VA-K-14 hydrochloride(VAK14 HCl) is a selective thyrotropin receptor (TSHR) antagonist (IC50= 12.3 μM) that inhibits TSHR stimulation by serum and monoclonal TSHR-stimulating antibodies from patients with GD and abrogates TSHR signaling.
Targets&IC50
TSHR:12.3 μM
AliasVAK14 Hydrochloride, VA-K-14 HCl, VAK14 HCl, VA K 14 HCl
Chemical Properties
Molecular Weight341.86
FormulaC18H16ClN3S
Cas No.1171341-19-7
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 55 mg/mL (160.88 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.9252 mL14.6259 mL29.2517 mL146.2587 mL
5 mM0.5850 mL2.9252 mL5.8503 mL29.2517 mL
10 mM0.2925 mL1.4626 mL2.9252 mL14.6259 mL
20 mM0.1463 mL0.7313 mL1.4626 mL7.3129 mL
50 mM0.0585 mL0.2925 mL0.5850 mL2.9252 mL
100 mM0.0293 mL0.1463 mL0.2925 mL1.4626 mL

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