Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Wighteone (Erythrinin B) is a small molecule compound derived from Genista ephedroides with potential antifungal and anticancer activity against EGFR L858R/T790M mutant non-small cell lung cancer.
Description | Wighteone (Erythrinin B) is a small molecule compound derived from Genista ephedroides with potential antifungal and anticancer activity against EGFR L858R/T790M mutant non-small cell lung cancer. |
In vitro | The limitations of currently available antifungal agents and the rapid emergence of drug-resistant strains necessitate more efficient approaches to screening and developing novel antifungal drugs. METHODS AND RESULTS: The antifungal activity of the natural products of a series of plants was evaluated and Wighteone, 5, 7, 4'-trihydroxy-6-(gamma,gamma-dimethylallyl)isoflavone showed excellent anti-yeast activity (MIC against Saccharomyces cerevisiae was 4 microg/ml). METHODS AND RESULTS: Transcriptome profiling of Wighteone-treated S. cerevisiae indicated that Wighteone is different from commonly used antifungal compounds in its mode of action. |
Synonyms | Erythrinin B, 6-Isopentenylgenistein |
Molecular Weight | 338.35 |
Formula | C20H18O5 |
CAS No. | 51225-30-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 80 mg/mL(236.44 mM), sonification is recommended.
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Wighteone 51225-30-0 Microbiology/Virology Antifungal Erythrinin B 6-Isopentenylgenistein inhibitor inhibit