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XY028-133

🥰Excellent
Catalog No. T13361Cas No. 2229974-73-4

XY028-133 is a PROTAC-based CDK4/6 degrader for the study of tumors.

XY028-133

XY028-133

🥰Excellent
Catalog No. T13361Cas No. 2229974-73-4
XY028-133 is a PROTAC-based CDK4/6 degrader for the study of tumors.
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Product Introduction

Bioactivity
Description
XY028-133 is a PROTAC-based CDK4/6 degrader for the study of tumors.
Chemical Properties
Molecular Weight1002.23
FormulaC53H67N11O7S
Cas No.2229974-73-4
SmilesCC(=O)c1c(C)c2cnc(Nc3ccc(cn3)N3CCN(CC3)C(=O)CCCCCC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)NCc3ccc(cc3)-c3scnc3C)C(C)(C)C)nc2n(C2CCCC2)c1=O
Relative Density.1.307 g/cm3 (Predicted)
Storage & Solubility Information
Storagekeep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 30 mg/mL (29.93 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM0.9978 mL4.9889 mL9.9777 mL49.8887 mL
5 mM0.1996 mL0.9978 mL1.9955 mL9.9777 mL
10 mM0.0998 mL0.4989 mL0.9978 mL4.9889 mL
20 mM0.0499 mL0.2494 mL0.4989 mL2.4944 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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