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XY101

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Purity:98.81%

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COA HPLC HNMR

XY101

Catalog No. T13362Cas No. 2349368-16-5

XY101 is a selective, metabolically stable and orally available agonist of RORγ inverse(IC50 of 30 nM and a Kd of 380 nM).

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Pack Size	Price	Availability
1 mg	$79	In Stock
5 mg	$173	In Stock
10 mg	$298	In Stock
25 mg	$475	In Stock
50 mg	$678	In Stock
100 mg	$912	In Stock
500 mg	$1,780	In Stock
1 mL x 10 mM (in DMSO)	$215	In Stock

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Product Introduction

Bioactivity

Description	XY101 is a selective, metabolically stable and orally available agonist of RORγ inverse(IC50 of 30 nM and a Kd of 380 nM).
In vitro	XY101 effectively inhibits cell growth, colony formation and expression of androgen receptor (AR), AR-V7 and prostate specific antigen (PSA)[1].
In vivo	XY101 demonstrates substantial antitumor effects, including inhibition of tumor growth, throughout the treatment period and is well-tolerated, evidenced by the absence of significant body weight loss[1].

Chemical Properties

Molecular Weight	563.48
Formula	C25H20F7NO4S
Cas No.	2349368-16-5

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 225 mg/mL (399.3 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7747 mL	8.8734 mL	17.7469 mL	88.7343 mL
5 mM	0.3549 mL	1.7747 mL	3.5494 mL	17.7469 mL
10 mM	0.1775 mL	0.8873 mL	1.7747 mL	8.8734 mL
20 mM	0.0887 mL	0.4437 mL	0.8873 mL	4.4367 mL
50 mM	0.0355 mL	0.1775 mL	0.3549 mL	1.7747 mL
100 mM	0.0177 mL	0.0887 mL	0.1775 mL	0.8873 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc