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3-Oxo-5β-cholanoic acid
🥰Excellent
Catalog No. T13502Cas No. 1553-56-6
Alias DHLCA, Dehydrolithocholic acid
3-Oxo-5β-cholanoic acid (Dehydrolithocholic acid) is a bile acid metabolite that inhibits TH17 cell differentiation by directly binding to the transcription factor RORγt with a Kd of 1.13 μM.
3-Oxo-5β-cholanoic acid
🥰Excellent
Purity: 99.77%
Catalog No. T13502Alias DHLCA, Dehydrolithocholic acidCas No. 1553-56-6
3-Oxo-5β-cholanoic acid (Dehydrolithocholic acid) is a bile acid metabolite that inhibits TH17 cell differentiation by directly binding to the transcription factor RORγt with a Kd of 1.13 μM.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 10 mg | 38 € | In Stock | |
| 25 mg | 59 € | In Stock | |
| 50 mg | 86 € | In Stock | |
| 1 mL x 10 mM (in DMSO) | 43 € | In Stock |
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Purity:99.77%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | 3-Oxo-5β-cholanoic acid (Dehydrolithocholic acid) is a bile acid metabolite that inhibits TH17 cell differentiation by directly binding to the transcription factor RORγt with a Kd of 1.13 μM. |
| In vitro | Treatment with 3-Oxo-5β-cholanoic acid significantly reduces the RORγt reporter's activity, likely by directly interacting with RORγt, thereby inhibiting TH17 cell differentiation by suppressing its transcriptional activity. |
| In vivo | 3-Oxo-5β-cholanoic acid (Dehydrolithocholic acid) (0.3% (w/w); p.o.; for 1 week) significantly reduces the percentage of ileal TH17 cells[1]. |
| Alias | DHLCA, Dehydrolithocholic acid |
| Molecular Weight | 374.56 |
| Formula | C24H38O3 |
| Cas No. | 1553-56-6 |
| Smiles | C[C@H](CCC(O)=O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C |
| Relative Density. | 1.31g/cm3 |
Storage & Solubility Information
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 65 mg/ml (173.54 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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