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RORγt Inverse agonist 6
🥰Excellent
Catalog No. T12753Cas No. 1887161-80-9
RORγt Inverse agonist 6 is an agonist of RORγt inverse. RORγt Inverse agonist 6 can be used in research on Th17-driven autoimmune diseases.
RORγt Inverse agonist 6
🥰Excellent
Purity: 98.65%
Catalog No. T12753Cas No. 1887161-80-9
RORγt Inverse agonist 6 is an agonist of RORγt inverse. RORγt Inverse agonist 6 can be used in research on Th17-driven autoimmune diseases.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $56 | In Stock | |
| 5 mg | $143 | In Stock | |
| 10 mg | $212 | In Stock | |
| 25 mg | $340 | In Stock | |
| 50 mg | $461 | In Stock | |
| 100 mg | $592 | In Stock | |
| 200 mg | $783 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $177 | In Stock |
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Purity:98.65%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | RORγt Inverse agonist 6 is an agonist of RORγt inverse. RORγt Inverse agonist 6 can be used in research on Th17-driven autoimmune diseases. |
| In vivo | RORγt Inverse agonist 6 (30 mg/kg; p.o.) inhibits the expression level of IL-17A by 59% compared to the vehicle after the oral administration at the tested dose. RORγt Inverse agonist 6 suppresses IL-17A gene expression by IL-23 stimulation in a mouse pharmacodynamics model. RORγt Inverse agonist 6 (1 mg/kg; p.o.) exhibits improved drug exposure with AUC of 1289 ng h/mL[1]. |
| Molecular Weight | 565.02 |
| Formula | C28H29ClN6O5 |
| Cas No. | 1887161-80-9 |
| Smiles | CC(C)n1c2ccc(NC(=O)N3CCO[C@H](C3)C(=O)Nc3ccc(C#N)c(Cl)c3)cc2c(=O)n(CC2CC2)c1=O |
| Relative Density. | 1.46 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 45 mg/mL (79.64 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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