Shopping Cart

Remove All

Your shopping cart is currently empty

AZD-0284

Select Batch

Purity:99.75%

Resource Download

COA HPLC HNMR

AZD-0284

Catalog No. T14369Cas No. 2101291-07-8

AZD-0284 is an inverse agonist of the nuclear receptor RORγ. In development for the treatment of plaque psoriasis vulgaris and respiratory tract disorders[1].

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Pack Size	Price	Availability
1 mg	$89	In Stock
2 mg	$133	In Stock
5 mg	$228	In Stock
10 mg	$347	In Stock
25 mg	$538	In Stock
50 mg	$778	In Stock
100 mg	$987	In Stock
1 mL x 10 mM (in DMSO)	$266	In Stock

Bulk & Custom

Add to Cart

Questions

Related Compound Libraries of "AZD-0284"

Product Introduction

Bioactivity

Description	AZD-0284 is an inverse agonist of the nuclear receptor RORγ. In development for the treatment of plaque psoriasis vulgaris and respiratory tract disorders[1].
Targets&IC50	RORγ:7.4(pIC50)
In vitro	AZD0284 (0.37 μM; 5 days) inhibits IL-17A production in human TH17 cells[1], reduces polarization of TH17 into pathogenic TH17/1 cells, decreases the frequency of IL-17+ cells and double positive TH17/1 cells, and reduces IL-17A secretion and RNA expression of IL-17A, IL-17F, IL-22, and IL-23R[1][2].

Chemical Properties

Molecular Weight	524.43
Formula	C21H18F6N2O5S
Cas No.	2101291-07-8

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 99 mg/mL (188.77 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9068 mL	9.5342 mL	19.0683 mL	95.3416 mL
5 mM	0.3814 mL	1.9068 mL	3.8137 mL	19.0683 mL
10 mM	0.1907 mL	0.9534 mL	1.9068 mL	9.5342 mL
20 mM	0.0953 mL	0.4767 mL	0.9534 mL	4.7671 mL
50 mM	0.0381 mL	0.1907 mL	0.3814 mL	1.9068 mL
100 mM	0.0191 mL	0.0953 mL	0.1907 mL	0.9534 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc