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Z-VEID-FMK

Catalog No. T23555 CAS T23555

When compared to other Caspase inhibitors, Z-DRHD-FMK inhibited Caspase 6 activity more effectively than the general Caspase inhibitor of Z-Val-Ala-Asp (OMe)-fluoromethy ketone (Z-VAD-FMK) or the Caspase 6 inhibitor Z-Val-Glu(Ome)-Ile-Asp(OMe)-fluoromethyl ketone. However, it was less effective in inhibiting TNFα-induced Apoptosis than Z-VAD-FMK or Z-VEID-FMK, presumably.

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Z-VEID-FMK, CAS T23555

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	When compared to other caspase inhibitors, Z-DRHD-FMK inhibited caspase 6 activity more effectively than the general caspase inhibitor of Z-Val-Ala-Asp (OMe)-fluoromethy ketone (Z-VAD-FMK) or the caspase 6 inhibitor Z-Val-Glu(Ome)-Ile-Asp(OMe)-fluoromethyl ketone. However, it was less effective in inhibiting TNFα-induced apoptosis than Z-VAD-FMK or Z-VEID-FMK, presumably.
In vitro	The caspase-6-specific inhibitor Z-VEID- FMK and general caspase inhibitors significantly prevent apoptosis of caspase-6-microinjected neurons2. Z-VEID-FMK, which inhibits caspase-6, was also able to abolish the cleavage of procaspase-8, although caspase-6 is activated downstream of caspase-8 in Fas-mediated apoptosis3.

Molecular Weight	652.71
Formula	C31H45FN4O10
CAS No.	T23555

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: ≥113.4mg/mL

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Su, Kuan-Wei, et al. Repurposing cabozantinib with therapeutic potential in KIT-driven t (8; 21) acute myeloid leukaemias. Cancer Gene Therapy . (2021): 1-14.

Citations

1. Su, Kuan-Wei, et al. Repurposing cabozantinib with therapeutic potential in KIT-driven t (8; 21) acute myeloid leukaemias.. Cancer Gene Therapy. 2022 May;29(5):519-532. doi: 10.1038/s41417-021-00329-1. Epub 2021 Apr 8.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Z-VEID-FMK T23555 Others Z VEID FMK ZVEIDFMK Inhibitor inhibitor inhibit

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